3228-02-2Relevant academic research and scientific papers
Preparation method 3 - methyl -4 - isopropylphenol (by machine translation)
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Paragraph 0039-0050, (2020/10/04)
The invention discloses a preparation method of 3 - methyl -4 - isopropyl phenol, and belongs to the technical field of organic synthesis. The method comprises the following steps: (1) reacting m-cresol with a base under 5 - 20 °C conditions in water; (2) separating the intermediate A and the triphosgene in an organic solvent A, and separating the organic phase to obtain the intermediate C; (20 - 50 °C) the intermediate C is obtained by hydrolyzing the intermediate C in an organic solvent B under 3 conditions and separating the organic phase to obtain an intermediate C; (5 - 15 °C) the intermediate C is obtained by hydrolyzing the intermediate C in an organic solvent B in an organic solvent B in an organic 50 - 90 °C. solvent B in an organic solvent B and in an organic solvent B. The reaction is complete. 97% 4. The intermediate C is obtained by hydrolyzing the 70% intermediate C in an organic solvent B in an organic solvent B in an organic solvent B. (by machine translation)
METHOD FOR PRODUCING ALKYLPHENOLS
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Paragraph 0053-0057; 0060-0094, (2019/12/05)
PROBLEM TO BE SOLVED: To provide an economically excellent and industrially advantageous method for producing 6-tert-butyl-4-isopropyl-3-methylphenol and 4-isopropyl-3-methylphenol. SOLUTION: The method for producing 6-tert-butyl-4-isopropyl-3-methylphenol by isopropylation of 6-tert-butyl-3-methylphenol is characterized by using an isopropylating agent in an amount of 1.0 mol equivalent or more based on 6-tert-butyl-3-methylphenol. The method for producing 4-isopropyl-3-methylphenol comprises subjecting 6-tert-butyl-4-isopropyl-3-methylphenol produced by the above-mentioned production method to debutylation. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT
Selective alkylation of m-cresol with isopropyl alcohol under solvent-free conditions
Teodorescu, Florina,Enache, Adrian,Sandulescu, Madalina
, p. 58 - 66 (2017/07/26)
The outcome of the solvent free alkylation of m-cresol with isopropyl alcohol over strong acid resin catalyst has been investigated under microwave irradiation as well as conventional heating. The various reaction parameters like catalyst amount, mole rat
PRODUCTION METHOD OF DIALKYLPHENOL
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Paragraph 0031, (2016/12/07)
PROBLEM TO BE SOLVED: To provide a method of producing a dialkylphenol safely in a high yield which causes a reaction to proceed under relatively low temperature and pressure conditions. SOLUTION: A method of producing a dialkylphenol comprises reacting m-cresol with an organic acid isopropyl ester, such as isopropyl acetate, in the presence of a zeolite type catalyst, especially β-type zeolite catalyst at a reaction pressure of about 0-1.0 MPa and a reaction temperature of about 180-200°C to obtain a dialkylphenol, such as 4-isopropyl-3-methylphenol or thymol. COPYRIGHT: (C)2016,JPOandINPIT
Improving carbon retention in biomass conversion by alkylation of phenolics with small oxygenates
Nie, Lei,Resasco, Daniel E.
, p. 14 - 21 (2013/02/25)
Alkylation of phenolics with alcohols is an efficient way to retain carbon from small oxygenates in the liquid products of pyrolysis bio-oil. In this contribution, we have investigated the alkylation of m-cresol with several alkylating agents over H-Beta zeolite. The alkylation activity follows the sequence 2-propanol > propylene > 1-propanol. In all cases, propylene is the actual alkylation agent since the alcohols dehydrate at a faster rate than the rate of alkylation. A two-stage process is proposed to convert fractions of bio-oil rich in small aldehydes and ketones together with phenolics. In the first stage, aldehydes and ketones are selectively hydrogenated to alcohols. In the second stage, the resulting alcohols alkylate the phenolic compounds and get incorporated into the upgraded liquid. To illustrate this concept, two consecutive catalyst beds have been used. The first bed contains a metal catalyst for the selective hydrogenation. Among several catalysts investigated, Cu/SiO2 and Pt-Fe/SiO2 were found to exhibit good selectivity to hydrogenate the aldehyde and ketone, respectively, while preserving the aromatic ring of the phenolic compound. The second bed contains an H-Beta zeolite for the alkylation stage.
Chloroindate(iii) ionic liquids as catalysts for alkylation of phenols and catechol with alkenes
Gunaratne, H. Q. Nimal,Lotz, Tobias J.,Seddon, Kenneth R.
scheme or table, p. 1821 - 1824 (2011/01/07)
Chloroindate(iii) ionic liquids are shown to be versatile catalysts for the alkylation of phenols with alkenes, giving high conversions to alkylated phenols with high selectivities.
Zirconia-modified superacid UDCaT-5: An efficient and versatile catalyst for alkylation reactions under solvent-free conditions
Yadav, Ganapati D.,Pathre, Ganesh S.
, p. 2684 - 2691 (2008/12/22)
UDCaT-5, a modified version of zirconia, efficiently catalyzes alkylation of phenols with alcohols under environmentally safe, heterogeneous reaction conditions with high selectivity and in excellent yields. The high content present in UDCaT-5 with preservation of tetragonal phase of zirconia was responsible for the superactivity. Several phenolic compounds carrying either electron-sulfer releasing or electron-withdrawing substituents in the ortho, meta, and para positions afforded high yields of the products. Copyright Taylor & Francis Group, LLC.
ALKYLATION OF HYDROXYARENES WITH OLEFINS, ALCOHOLS AND ETHERS IN IONIC LIQUIDS
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Page/Page column 20-21, (2008/06/13)
Hydroxyarenes are alkylated using an ionic liquid catalyst system with olefins, alcohols, or ethers as alkylating agents. The ionic liquid catalyst system comprises chloroindate (III) anions. The reactions may be conducted at moderate temperatures and pressures to yield commercially relevant alkylated hydroxyarene compounds.
ISOPROPYLMETHYLPHENOL GLYCOSIDE
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Page/Page column 5, (2008/06/13)
PROBLEM TO BE SOLVED: To provide an isopropylmethylphenol derivative exhibiting excellent antibacterial actions, antioxidation actions, scalp dandruff and itching-preventing actions, pimple symptom-ameliorating actions and carious tooth and periodontal disease-preventing actions, and a skin care preparation for external uses and a hair cosmetic containing the same. SOLUTION: The isopropylmethylphenol glycoside is represented by formula (1) (wherein R is a residue of a sugar selected from the group consisting of glucose, xylose and maltose). The skin care preparation for external uses and the hair cosmetic contain the isopropylmethylphenol glycoside.
2DCOR-GC: An application of the generalized two-dimensional correlation analysis as a route to optimization of continuous flow supercritical fluid reactions
Hyde, Jason R.,Bourne, Richard A.,Noda, Isao,Stephenson, Phil,Poliakoff, Martyn
, p. 6197 - 6206 (2007/10/03)
A new approach for optimization and monitoring of continuous reactions has been developed using 2D correlation methods for the analysis of GC data (2DCOR-GC). 2DCOR-GC maps are obtained following perturbation of the system that allow the effect of changing reaction parameters such as time, temperature, pressure, or concentration to be both monitored and sequenced with regard to changes in the raw GC data. In this paper, we describe the application of the 2DCOR-GC technique to monitoring the reverse water-gas shift reaction in scCO2. 2DCOR-GC is combined with FT-IR data to validate the methodology. We also report the application of 2DCOR-GC to probe the mechanism of the alkylation of m-cresol with isopropyl alcohol in scCO2 using Nafion SAC-13 as the catalyst. These results identify coeluting peaks that could easily be missed without exhaustive method development.
