1762-66-9

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 100-52-7 benzaldehyde 
• 109-89-7 diethylamine 
• 75861-69-7 trans-3-Phenylpropenoyl isothiocyanate 
• 1762-62-5 2-diethylamino-thiazol-4-one 
• 78374-78-4 N,N-diethyl-N'-3-phenylpropenoylthiourea 

Relevant academic research and scientific papers

Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones

2-Amino-5-alkylidene-thiazol-4-ones bearing two diversity points are prepared by a solid-phase strategy exploiting rhodanine as the starting material. Rhodanine is first loaded on bromo-Wang resin, subjected to Knovenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine.

SYNTHESIS OF 2-SUBSTITUTED 5-ARYLIDENETHIAZOLIN-4-ONES FROM α,β-UNSATURATED ACYL ISOTHIOCYANATES

α,β-Unsaturated acyl isothiocyanates react with N-methylaniline to give thioureas which, when treated with bromine in chloroform, afford benzothiazoline derivatives.Under the same reaction conditions primary amines, diethylamine,piperidine and morpholine