17640-25-4

Basic information

• Product Name: DICHLOROMETHOXYACETIC ACID METHYL ESTER
• Synonyms: METHYL DICHLOROMETHOXYACETATE;METHYL 2,2-DICHLORO-2-METHOXYACETATE;DICHLOROMETHOXYACETIC ACID METHYL ESTER;METHYL 2,2-DICHLORO-2-METHOXYACETATE, 97 %;METHOXYDICHLOROACETIC ACID METHYL ESTER;METHYL DICHLOROMETHOXYACETATE TECH., 90%;Methyl dichloromethoxyacetate,90%,tech.;Methyl dichloroMethoxyacetate, tech., 90% 25ML
• CAS NO: 17640-25-4
• Molecular Formula: C₄H₆Cl₂O₃
• Molecular Weight: 172.99
• Product Categories: C2 to C5;Carbonyl Compounds;Esters
• Mol File: 17640-25-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 179-181 °C(lit.)
• Flash Point: 195 °F
• Appearance: Clear colorless/Liquid
• Density: 1.36 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.915mmHg at 25°C
• Refractive Index: n20/D 1.45(lit.)
• Storage Temp.: Refrigerator
• CAS DataBase Reference: DICHLOROMETHOXYACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: DICHLOROMETHOXYACETIC ACID METHYL ESTER(17640-25-4)
• EPA Substance Registry System: DICHLOROMETHOXYACETIC ACID METHYL ESTER(17640-25-4)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37-36/37/38-26/27/28
• Safety Statements: 23-26-27-36/37/39-45-24/25
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 17640-25-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless liquid

Uses

Methyl 2,2-dichloro-2-methoxyacetate was used in the preparation of methyl (Z)-α-methoxyacrylates via stereospecific two-carbon homologation of aldehydes under Barbier conditions.

InChI:InChI=1/C4H6Cl2O3/c1-8-3(7)4(5,6)9-2/h1-2H3

Upstream product

• 553-90-2 Dimethyl oxalate 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 93168-69-5 Oxalsaeure-methyl-(2,4-dichlor-phenylester) 
• 75-00-3 chloroethane 
• 66298-75-7 phosphonic dichloride 
• 109-69-3 n-Butyl chloride 
• 66298-77-9 phosphonic difluoride 
• 18370-95-1 methyl 2,2,2-trimethoxyacetate 
• 5180-78-9 methyl 2-(2-methoxyphenyl)-2-oxoacetate 
• 32766-61-3 4-methoxyphenylglyoxylate methyl ester 
• 34404-83-6 methyl 2,4,6-trimethylphenylgloxylate 
• 553-90-2 Dimethyl oxalate 
• 650-20-4 ethyl ethylphosphonofluoridate 
• 865-61-2 ethylphosphonic chloride fluoride 
• 665-03-2 methyl ethylphosphonofluoridate 
• 67538-58-3 ethyl phosphonofluoridate 

Relevant articles and documents

INHIBITORS OF PI3K-DELTA AND METHODS OF THEIR USE AND MANUFACTURE

The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

SYNTHESIS OF α,β-EPOXY DIAZOMETHYL KETONES

The preparation of eighteen epoxy diazomethyl ketones 1 is described.Two general methods were developed.Firstly, treatment of the mixed anhydrides of glycidic acids and carbonic acid ester with diazomethane led to the title compounds in yields ranging from 17-74 percent.Secondly, glycidyl chlorides which were obtained from sodium glycidates and oxalyl chloride, gave the desired products upon treatment with diazomethane ( yields 60-74 percent).The required α,β-epoxy carboxylic esters were prepared by Darzens condensation and epoxidation of α,β-unsaturated esters, but in some cases also by reaction of α-oxo carboxylic esters with diazomethane.