17642-90-9

Basic information

• Product Name: 2H-Azepine-2-thione, hexahydro-1-(phenylmethyl)-
• Synonyms: 2H-Azepine-2-thione, hexahydro-1-(phenylmethyl)-
• CAS NO: 17642-90-9
• Molecular Formula: C₁₃H₁₇NS
• Molecular Weight: 0
• Mol File: 17642-90-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2H-Azepine-2-thione, hexahydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Azepine-2-thione, hexahydro-1-(phenylmethyl)-(17642-90-9)
• EPA Substance Registry System: 2H-Azepine-2-thione, hexahydro-1-(phenylmethyl)-(17642-90-9)

Safety Data

• Hazardous Substances Data: 17642-90-9(Hazardous Substances Data)

Usage

General Description

2H-Azepine-2-thione, hexahydro-1-(phenylmethyl)- is a chemical compound with the molecular formula C13H17NOS. It is a heterocyclic compound containing a sulfur atom and a seven-membered ring with a nitrogen atom. This chemical is also known as thiazepine and is used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It has potential applications in the treatment of psychiatric disorders and as an intermediate in the production of pharmaceuticals. Additionally, it has been studied for its potential biological activities and therapeutic properties.

Upstream product

• 105-60-2 caprolactam 
• 100-39-0 benzyl bromide 
• 33241-96-2 1-Benzyl-hexahydro-azepin-2-on 

Downstream Products

• 1017237-89-6 1-benzyl-7-methylsulfanyl-3,4,5,6-tetrahydro-2H-azepinium iodide 
• 1017238-02-6 1-benzyl-2,2-dibutylazepane 
• 109741-21-1 (E)-4-(1-benzyl-2-dimethoxymethylpiperidin-2-yl)-3-buten-2-one 
• 109741-17-5 1-benzyl-2-methylthio-4,5,6,7-tetrahydro-1H-azepine-3-carbaldehyde 
• 109741-20-0 1-benzyl-2-dimethoxymethylpiperidine-2-carbaldehyde 
• 109741-18-6 1-benzyl-4,5,6,7-tetrahydro-1H-azepine-3-carbaldehyde 
• 77204-60-5 1-benzyl-1-azaspiro<5.5>undec-7-en-9-one 
• 33241-96-2 1-Benzyl-hexahydro-azepin-2-on 
• 109741-16-4 1-benzyl-2-thioxohexahydroazepine-3-carbaldehyde 

Relevant articles and documents

Reductive Alkylation of Tertiary Lactams via Addition of Organocopper (RCu) Reagents to Thioiminium Ions

A simple procedure for the conversion of tertiary lactams to 2-monoalkylated cyclic amines is described. The reaction sequence involves conversion of a lactam to a thioiminium ion followed by reaction with an organocopper (RCu) reagent and final reduction with triacetoxyborohydride. The reaction is high yielding and shows an excellent functional group tolerance. Its utility is demonstrated by a rapid synthesis of indolizidine 167B. The excellent chemoselectivity of the process, where only monoalkylation products are formed, is rationalized by a mechanism involving the formation of a transient enamine.

An efficient method to convert lactams and amides into 2,2-dialkylated amines

(Chemical Equation Presented) A practical method for the synthesis of gem-2,2-disubstituted tertiary amines from the corresponding lactams (or amides) is reported. It is based on the reaction of thioiminium ions, easily prepared from lactams and amides wi