176515-40-5

Upstream product

• 176515-41-6 9-benzyl-6-chloro-2-iodo-9H-purine 
• 98-80-6 phenylboronic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 424830-65-9 N⁴-benzyl-6-chloro-2-phenyl-pyrimidine-4,5-diamine 
• 10310-21-1 2-Amino-6-chloropurin 
• 6336-42-1 2-amino-9-benzyl-6-chloro-9H-purine 
• 100-44-7 benzyl chloride 
• 3815-69-8 5-amino-1-(phenylmethyl)-1H-imidazole-4-carboxamide 
• 93-89-0 benzoic acid ethyl ester 
• 640274-20-0 9-benzyl-2-phenyl-9H-purin-6-ol 
• 960-16-7 tributylphenylstannane 
• 176515-42-7 9-benzyl-2-bromo-6-chloro-9H-purine 

Downstream Products

• 1064711-66-5 N⁶-(4-nitrophenyl)-9-benzyl-2-phenyladenine 
• 640274-34-6 9-benzyl-2-phenyladenine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects

Recently we reported the adenine derivatives (2-4) as new interferon (IFN) inducers. In the present study, we conducted a detailed structure and activity relationship study of 4 and its related derivatives on IFN inducing activity. From this study, we found that compound 4 exhibited the most potent IFN inducing activity in vitro with a minimum effective concentration of 0.01 μM, and 4 also showed strong IFN-inducing activity at doses of more than 0.3 mg/kg by oral administration in mice. This potency was 10-fold stronger than that of Imiquimod. Moreover, 4 did not cause emesis in ferrets even at doses as high as 10 mg/kg, whereas, 80% of animals were emetic when orally administered with the same dose of Imiquimod. These results indicate that compound 4 is superior to Imiquimod with respect to efficacy and safety.

N6-cycloalkyl-2-phenyl-3-deaza-8-azaadenines: a new class of A1 adenosine receptor ligands. A comparison with the corresponding adenines and 8-azaadenines.

Several 9-benzyl-N6-cycloalkyl-2-phenyladenines, 9-benzyl-N6-cycloalkyl-2-phenyl-8-azaadenines and 4-cycloalkylamino-1-benzyl-6-phenyl-1H-1,2,3-triazolo[4,5-c]pyridines were prepared and assayed as A1 adenosine receptor ligands. The 1H-1,2,3-triazolo[4,5-

The Suzuki-Miyaura cross-coupling reactions of 2-, 6- or 8-halopurines with boronic acids leading to 2-, 6- or 8-aryl- and -alkenylpurine derivatives

The Suzuki-Miyaura cross-coupling reactions of 9-benzyl-6-chloropurine, 9- or 3-benzyl-8-bromoadenine and 2,6-dihalopurines with boronic acids gave the corresponding 6-, 8- or 2-aryl- or -alkenylpurines in good yields. Anhydrous conditions in toluene were

Regiochemistry in Stille couplings of 2,6-dihalopurines

The regiochemistry in Stille couplings of 2,6-dihalopurines have been studied. 2,6-Dichloropurines react selectively in the 6-position, and 6-chloro-2-iodopurines and 2-bromo-6-chloropurines in the 2-position.