176648-09-2

Basic information

• Product Name: 1-Chloro-4-phenyl-3-butyn-2-one
• Synonyms: 1-Chloro-4-phenyl-3-butyn-2-one
• CAS NO: 176648-09-2
• Molecular Formula: C₁₀H₇ClO
• Molecular Weight: 178.61498
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 176648-09-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Chloro-4-phenyl-3-butyn-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-phenyl-3-butyn-2-one(176648-09-2)
• EPA Substance Registry System: 1-Chloro-4-phenyl-3-butyn-2-one(176648-09-2)

Safety Data

• Hazardous Substances Data: 176648-09-2(Hazardous Substances Data)

Usage

Uses

1-Chloro-4-phenyl-3-butyn-2-one is an intermediate used in reactions with organometallic reagents.

Upstream product

• 1004-22-4 (phenylethynyl)sodium 
• 79-04-9 chloroacetyl chloride 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 593-71-5 Chloroiodomethane 
• 132960-13-5 N-methoxy-N-methyl-3-phenyl-2-propynamide 
• 536-74-3 phenylacetylene 
• 67442-07-3 2-chloro-N-methoxy-N-methylacetamide 

Downstream Products

• 128165-52-6 (+/-)-2-(phenylethynyl)oxirane 
• 591218-51-8 (2R,3E)-1-chloro-4-phenylbut-3-en-2-ol 
• 433257-35-3 (S)-1-Chloro-4-phenyl-but-3-yn-2-ol 
• 433257-34-2 (R)-1-Chloro-4-phenyl-but-3-yn-2-ol 

Relevant articles and documents

Electron-deficient alkynes as powerful tools against root-knot nematode melodogyne incognita: Nematicidal activity and investigation on the mode of action

The present study reports on the powerful nematicidal activity of a series of electron-deficient alkynes against the root-knot nematode Meloidogyne incognita (Kofoid and White) Chitwood. Interestingly, we found that the conjugation of electronwithdrawing carbonyl groups to an alkyne triple bond was extremely proficient in inducing nematode paralysis and death. In particular, dimethylacetylenedicarboxylate (10), 3-butyn-2-one (1), and methyl propiolate (4), with EC50/48 h of 1.54 ± 0.16, 2.38 ± 0.31, and 2.83 ± 0.28 mg/L, respectively, were shown to be the best tested compounds. Earlier studies reported on the ability of alkynoic esters and alkynones to induce a chemoselective cysteine modification of unprotected peptides. Thus, also following our previous findings on the impairment of vacuolar-type proton translocating ATPase functionality by activated carbonyl derivatives, we speculate that the formation of a vinyl sulfide linkage might be responsible for the nematicidal activity of the presented electrondeficient alkynes.

Chemo-, regio-, and stereo-selective perfluoroalkylations by a Grignard complex with zirconocene

The synthesis of highly reactive perfluoroalkyl Grignard reagents with early transition metal zirconocene complexes and their new types of highly chemo-, regio-, and stereo-selective perfluoroalkylation reactions are reported with epoxides in particular. The zirconocene complex is advantageous in activating the perfluoroalkyl Grignard species. The zirconocene·Grignard complexes were clarified by DOSY. Both 1H and 19F DOSY analyses show that the addition of MAO and dioxane to the mixture of RFMgCl and Cp2ZrCl2 connects Cp2Zr and RFMg to generate the zirconocene/perfluoroalkyl-Grignard/dioxane complex.

A versatile route to (E)- and (Z)-2-hydroxy-3,4-unsaturated disubstituted sulfilimines and their haloamidation reaction

(Chemical Equation Presented) α-Chloro ynones have been reduced using Noyori's Ru catalyst to furnish R-chloro propargylic alcohols with excellent enantioselectivity. These have been used as a common precursor for the preparation of (E)- and (Z)-2-hydroxy