176750-70-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-6-hydroxy-benzoic acid Methyl ester is used as a precursor in the synthesis of pharmaceutical compounds for its ability to be chemically modified to create new drug molecules, contributing to the development of novel treatments and therapies.
Used in Agricultural Industry:
In agriculture, 2-Chloro-6-hydroxy-benzoic acid Methyl ester serves as a starting material for the production of agrochemicals, potentially enhancing crop protection and yield through the development of new pesticides or other agricultural chemicals.
Used in Material Science:
2-Chloro-6-hydroxy-benzoic acid Methyl ester is utilized in the development of new materials, leveraging its chemical properties to create innovative substances with specific characteristics for various industrial applications.
Used as a Reagent in Organic Chemistry:
2-Chloro-6-hydroxy-benzoic acid Methyl ester also functions as a reagent in organic chemistry reactions, facilitating specific transformations and syntheses that are essential in the preparation of complex organic molecules.

Upstream product

• 67-56-1 methanol 
• 56961-31-0 6-chloro-2-hydroxybenzoic acid 

Downstream Products

• 902143-88-8 methyl 2-chloro-6-(methoxymethyl)benzoate 

Relevant academic research and scientific papers

4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORGAMMAT INHIBITORS AND USES THEREOF

Provided are compounds according to Formula I or a pharmaceutically acceptable salt or solvate thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF

The present invention relates to compounds according to Formula I (Formula I), and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

Zatosetron, a Potent, Selective, and Long-Acting 5HT3 Receptor Antagonist: Synthesis and Structure-Activity Relationships

Antagonists of 5HT3 receptors are clinically effective in treating nausea and emesis associated with certain oncolytic drugs, including cisplatin.Moreover, these agents may be useful in pharmacological management of several central nervous system disorders, including anxiety, schizophrenia, dementia, and substance abuse.Our studies on aroyltropanamides led to the discovery that dihydrobenzofuranyl esters and amides are potent 5HT3 receptor antagonists.Simple benzoyl derivatives of tropine and 3α-aminotropane possessed weak 5HT3 receptor antagonist activity, as judged by blockade of bradycardia produced by iv injection of serotonin (5HT) to anesthetized rats.Within this series, use of benzofuran-7-carboxamide as the aroyl moiety led to a substantial increase of 5HT3 receptor affinity.The optimal 5HT3 receptor antagonist identified via extensive SAR studies was endo-5-chloro-2,3-dihydro-2,2-dimethyl-N-(8-methyl-8-azabicyclooct-3-yl)-7-benzofurancarboxamide (Z)-2-butenedioate (zatosetron maleate).The 7-carbamyl regiochemistry, dimethyl substitution, chloro substituent, and endo stereochemistry were all crucial elements of the SAR.Zatosetron maleate was a potent antagonist of 5HT-induced bradycardia in rats (ED50=0.86 μg/kg iv).Low oral doses of zatosetron (30 μg/kg) produced long-lasting antagonism of 5HT3 receptors, as evidenced by blockade of 5HT-induced bradycardia for longer than 6 h in rats.Moreover, this compound did not produce hemodynamic effects after iv administration to rats, nor did it block carbamylcholine-induced bradycardia in doses that markedly blocked 5HT3 receptors.Thus, zatosetron is a potent, selective, orally effective 5HT3 receptor antagonist with a long duration of action in rats.