56961-31-0

Usage

Uses

Used in Pharmaceutical Industry:
6-Chlorosalicylic Acid is used as a precursor for the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs due to its chemical properties that facilitate the creation of diverse medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Chlorosalicylic Acid is utilized as a starting material for the production of various agrochemicals, contributing to the development of products that enhance crop protection and yield.
Used in Dye Industry:
6-Chlorosalicylic Acid is used as a chemical intermediate in the synthesis of dyes, enabling the production of a wide array of colorants for different applications, including textiles and other industrial uses.
Used in Chemical Production:
6-Chlorosalicylic Acid is used as a component in the manufacturing of UV absorbers, which are essential in various products to protect against the harmful effects of ultraviolet radiation.
Used in Flame Retardant Industry:
6-Chlorosalicylic Acid is also employed in the production of flame retardants, which are critical in imparting fire resistance to materials used in construction, textiles, and other industries.
Used in Antioxidant Production:
6-Chlorosalicylic Acid is used in the synthesis of antioxidants, which are vital in various applications to prevent oxidation in products, thereby extending their shelf life and enhancing their stability.

InChI:InChI=1/C7H5ClO3/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,9H,(H,10,11)

Upstream product

• 118-91-2 ortho-chlorobenzoic acid 
• 434-75-3 2-chloro-6-fluorobenzoic acid 
• 108-43-0 3-monochlorophenol 
• 124-38-9 carbon dioxide 
• 100960-33-6 2-amino-6-chlorobenzoic acid hydrochloride 
• 91105-99-6 1-chloro-3-(methoxymethoxy)benzene 

Downstream Products

• 71752-93-7 2-Allyloxy-6-chloro-benzoic acid 
• 1094627-55-0 3-chloro-2-(hydroxymethyl)phenol 
• 176750-70-2 methyl 2-chloro-6-hydroxybenzoate 

Relevant academic research and scientific papers

Palladium-catalyzed ortho-C-H hydroxylation of benzoic acids

A simple Pd(OAc)2 catalyzed ortho-hydroxylation of benzoic acids using TBHP as the sole oxidant has been explored. This protocol features relatively broad substrate scope and operational simplicity. The compatibility of ortho-substituted substrates is an effective complement to the previous ortho-hydroxylation reaction.

Chlorinated cobalt alkyne complexes derived from acetylsalicylic acid as new specific antitumor agents

[(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), an organometallic derivative of the irreversible cyclooxygenase-1/2 (COX-1/2) inhibitor acetylsalicylic acid (ASS), demonstrated high growth-inhibitory potential against various tumor cell lines and inhibition of both COX isoenzymes. With the objective of increasing the selectivity for COX-2, we introduced a chlorine substituent in position 3, 4, 5, or 6 of the ASS moiety, respectively. Increased COX-2 selectivity is desirable as this isoenzyme is predominantly related to the development of cancer and abnormal tissue growth. The new compounds were investigated in comprehensive cellular biological assays to identify the impact of the chlorine substitution at the complex on COX-1/2 inhibition, antiproliferative activity, apoptosis, metabolic activity, cell-based COX inhibition, and cellular uptake. Chlorination distinctly reduced the effects at isolated COX-1 (about 25% inhibition at 10 μM; Co-ASS: 82.7%), while those at COX-2 remained almost unchanged (about 65% inhibition at 10 μM; Co-ASS: 78.5%). In cellular systems, with exception of the 6-Cl derivative, all compounds showed notable antitumor activity in COX-1/2 expressing tumor cells (HT-29 (IC50 = 1.5-2.7 μM), MDA-MB-231 (IC50 = 5.2-8.0 μM)), but were distinctly less active in the COX-1/2-negative MCF-7 breast cancer cell line (IC50 = 15.2-22.9 μM). All complexes possess high selectivity for tumor cells, because they did not influence the growth of the non-tumorigenic, human bone marrow stromal cell line HS-5. These findings clearly demonstrate that the interference with the COX-1/2 cascade contributes to the mode of anticancer action of the cobalt alkyne complexes.

Carboxylation of Phenols with CO2 at Atmospheric Pressure

A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.

N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INHIBITORS

The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions or disorders such as allergic disorders, inflammatory disorders and disorders of the immune system.

The site-selective functionalization of halogen-bearing phenols: An exercise in diversity-oriented organometallic synthesis

The organometallic approach to diversity-oriented organic synthesis was subjected to a further test, this time in the phenol series. The model compounds selected were 2,3,6-trifluorophenol, the three isomers of (trifluoromethoxy) phenol and the three isomers of chlorophenol. A combination of optionally site selective metalations and protective group-controlled metalations enabled the selective generation of several isomeric intermediates in each case and their subsequent conversion into functionalized derivatives, in particular hydroxybenzoic acids.

Herbicidal substituted benzoylsulfonamides

Compound of the formula STR1 in which A is O, S, or NR3 ; G is CH or N; R and R1 are independently alkyl, alkoxy, haloalkoxy or alkylamino; R2 is phenyl, substituted phenyl, alkyl, cycloalkyl, haloalkyl or --CH2 [(R4)C(R5)n --Z; R3 and R7 are, independently, hydrogen, alkyl, --C(O)NH2 or --C(O)alkyl; R4 and R5 are independently hydrogen, alkyl, or halogen; R6 is halogen, alkyl, alkoxy, haloalkoxy, NO2, amino, alkyl substituted amino, or acyl substituted amino; n is 0 to 5; Z is cyano, amino, alkylamino, dialkylamino, --NHCO2 alkyl, alkoxy, alkylthio, alkylsulfonyl, alkenyl, alkynyl, phenyl or substituted phenyl; and Q is hydrogen, halogen, alkyl, alkoxy, haloalkoxy, nitro, amino, haloalkyl, alkythio, alkylsulfonyl, phenyl, substituted phenyl or phenoxy; or a 5 or 6 membered aromatic heterocycle having the formula STR2 in which "m" is 0 or 1; A' is O, S, or NR7 ; and X, X', Y, Y', W, W', V, V', U and Z' are independently N, O, S, --CH-- or --CR6. Intermediates for preparation of the benzoylsulfonamides are also disclosed.