176755-84-3Relevant academic research and scientific papers
Preparation of oligonucleotides containing 5-bromouracil and 5-methylcytidine
Ferrer, Elisenda,Fabrega, Carme,Garcia, Ramon Gueimil,Azorin, Ferran,Eritja, Ramon
, p. 907 - 921 (2007/10/03)
A previously described side reaction on 5-bromouracil during standard oligonucleotide deprotection conditions has been studied in detail. The side product, 5-amino-2′-deoxyuridine, is isolated and characterized. The use of several 5-methylcytidine protected derivatives for the preparation of oligonucleotides containing 5-bromouracil and 5-methylcytidine free of 5-amino-2′-deoxyuridine is discussed.
