126144-60-3

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 18293-54-4 1-trimethylsilyl-1,2,4-triazole 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 50-89-5 thymidine 

Downstream Products

• 117032-49-2 4-(1,2,4-triazol-1-yl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-trimethylsilyl thymidine 
• 176755-83-2 5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-5-methylcytidine 
• 176755-84-3 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide 
• 52417-09-1 3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine 
• 1020851-58-4 C₃₇H₄₃N₃O₆SeSi 
• 1239880-91-1 C₃₇H₄₅N₃O₆S₂ 
• 102573-69-3 5'-O-(4-4'-dimethoxytrityl)-N³-benzoyl thymidine 
• 847699-97-2 benzoic acid 5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 
• 104579-03-5 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxy-N⁴-benzoyl-5-methylcytidine 
• 105931-57-5 5-methyl dC amidite 

Relevant academic research and scientific papers

Synthesis and DNA-polymerase incorporation of colored 4-selenothymidine triphosphate for polymerase recognition and DNA visualization

Highlighting changes in yellow: The replacement of a single oxygen atom in thymidine triphosphate with a selenium atom gave yellow 4-selenothymidine 5′-triphosphate (SeTTP; see solutions of colorless natural TTP (left) and SeTTP (right)). SeTTP is recognized by DNA polymerase. Its incorporation into DNA (see scheme) yields colored DNA and occurs with the same level of efficiency as the incorporation of natural TTP. (Chemical Equation Presented)

Synthesis of thymidine dimers from 5′-O-aminothymidine

The synthesis of modified oligonucleotides is of great importance for various therapeutic and diagnostic applications. The facile secondary structure formation of N-oxyamide-linked peptide analogues and the high nucleophilicity of the aminooxy function prompted us to prepare O-amino nucleoside derived dinucleosides. Herein, the efficient synthesis of three novel thymidine dimers with N-oxyamide, oxime and oxyamine linkages via a convergent approach from a common 5-O-aminothymidine is reported. Georg Thieme Verlag Stuttgart · New York.

Antisense modulation of profilin 1 expression

Antisense compounds, compositions and methods are provided for modulating the expression of profilin 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding profilin 1. Methods of using these compounds for modulation of profilin 1 expression and for treatment of diseases associated with expression of profilin 1 are provided.

Preparation of oligonucleotides containing 5-bromouracil and 5-methylcytidine

A previously described side reaction on 5-bromouracil during standard oligonucleotide deprotection conditions has been studied in detail. The side product, 5-amino-2′-deoxyuridine, is isolated and characterized. The use of several 5-methylcytidine protected derivatives for the preparation of oligonucleotides containing 5-bromouracil and 5-methylcytidine free of 5-amino-2′-deoxyuridine is discussed.