176755-83-2

Basic information

• Product Name: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-
• Synonyms: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-;1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-4-imino-5-methyl-1,4-dihydropyrimidin-2-ol;5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methylcytidine
• CAS NO: 176755-83-2
• Molecular Formula: C₃₁H₃₃N₃O₆
• Molecular Weight: 543.61022
• Mol File: 176755-83-2.mol
• Article Data: 78

Chemical Properties

• Melting Point: 215-217 °C
• Boiling Point: 720.3±70.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 13.99±0.60(Predicted)
• CAS DataBase Reference: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-(176755-83-2)
• EPA Substance Registry System: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-5-methyl-(176755-83-2)

Safety Data

• Hazardous Substances Data: 176755-83-2(Hazardous Substances Data)

Upstream product

• 288-36-8 1,2,3-triazole 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 10025-87-3 trichlorophosphate 
• 7664-41-7 ammonia 
• 7732-18-5 water 
• 126144-60-3 3'-O-trimethylsilyl-5'-O-dimethoxytrityl-thymidine 
• 288-88-0 1,2,4-Triazole 
• 75-77-4 chloro-trimethyl-silane 
• 50-89-5 thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 117032-49-2 4-(1,2,4-triazol-1-yl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-3'-O-trimethylsilyl thymidine 

Downstream Products

• 176755-84-3 N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-isobutyramide 
• 104579-03-5 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-deoxy-N⁴-benzoyl-5-methylcytidine 
• 105931-57-5 5-methyl dC amidite 
• 847699-97-2 benzoic acid 5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 
• 838-07-3 5-methyldeoxycytidine 

Relevant articles and documents

Efficient large-scale synthesis of 5′-O-dimethoxytrityl-N 4-benzoyl-5-methyl-2′-deoxycytidine

An efficient process to synthesize 5′- O -dimethoxytrityl-N 4 -benzoyl-5-methyl-2 ′-deoxycytidine in high yield and quality is described. Final benzoylation was improved by developing a method to selectively hydrolyze benzoyl ester impurities. This inexpensive approach was scaled up to multi-kilogram quantities for routine use in oligonucleotide therapeutics. Copyright Taylor & Francis Group, LLC.

Modulation of DC-SIGN expression

Compounds, compositions and methods are provided for modulating the expression of DC-SIGN. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DC-SIGN. Methods of using these compounds for modulation of DC-SIGN expression and for diagnosis and treatment of diseases and conditions associated with expression of DC-SIGN are provided.

Antisense modulation of P2X4 expression

Antisense compounds, compositions and methods are provided for modulating the expression of P2X4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding P2X4. Methods of using these compounds for modulation of P2X4 expression and for treatment of diseases associated with expression of P2X4 are provided.