17682-05-2

Upstream product

• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 623-33-6 glycine ethyl ester hydrochloride 
• 4132-86-9 N-benzyloxycarbonylalanine 
• 1142-20-7 N-(benzyloxycarbonyl)-D-alanine 
• 35661-38-2 Fmoc-alanine 
• 459-73-4 GlyOEt*HCl 
• 83851-22-3 Z-L-Ala 

Downstream Products

• 34286-66-3 N-benzyloxycarbonyl-(R)alanyl-glycine 
• 96012-25-8 Boc-Tyr-D-Ala-Gly-Phe-Met-NHC₆H₁₃(n) 
• 96012-24-7 Boc-Tyr-D-Ala-Gly-Phe-Met-NHC₃H₇(iso) 
• 96022-24-1 Boc-Tyr-D-Ala-Gly-Phe-Met-NHC₂H₅ 
• 72719-81-4 Tyr-D-Ala-Gly-Phe-Met-NHC₆H₁₃(n) 
• 72719-79-0 Tyr-D-Ala-Gly-Phe-Met-NHC₃H₇(iso) 
• 72719-78-9 Tyr-D-Ala-Gly-Phe-Met-NHC₂H₅ 
• 96012-52-1 Boc-Tyr-D-Ala-Gly-OTcp 
• 77621-73-9 Boc-Tyr-D-Ala-Gly-OEt 
• 64410-47-5 Boc-Tyr-D-Ala-Gly 
• 3997-90-8 D-ala-gly 
• 72732-45-7 (S)-2-Amino-N-[(R)-1-({[(S)-1-benzyl-2-(N'-butyryl-hydrazino)-2-oxo-ethylcarbamoyl]-methyl}-carbamoyl)-ethyl]-3-(4-hydroxy-phenyl)-propionamide 
• 74085-15-7 [(S)-1-{(R)-1-[({(S)-1-Benzyl-2-[N'-(3-benzyloxycarbonylamino-propionyl)-hydrazino]-2-oxo-ethylcarbamoyl}-methyl)-carbamoyl]-ethylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester 
• 81378-57-6 Acetic acid 2-{N-acetyl-N'-[(S)-2-(2-{(R)-2-[(S)-2-benzyloxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionyl]-hydrazino}-ethyl ester 

Relevant academic research and scientific papers

The method of preparation of enantiomerically enriched products of condensation from racemic acids or acids of the low enentiomeric purity

The method of obtaining enantiomerically enriched condensation products consists of subjecting a racemic acid or an acid of low enantiomeric purity to the action of a condensing reagent - a chiral N-triazinylammonium tetrafluoroborate (formula 1), a chira

Design, synthesis, and application of enantioselective coupling reagent with a traceless chiral auxiliary

(Chemical Equation Presented) Stable chiral N-triazinylbrucinium tetrafluoroborate enantioselectively activates racemic carboxylic acids yielding enantiomerically enriched amides, esters, and dipeptides with er from 8:92 to 0.5:99.5. Due to the departure

A novel generation of coupling reagents. Enantiodifferentiating coupling reagents prepared in situ from 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and chiral tertiary amines

Coupling of racemic N-protected amino acids with amino components by means of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) in the presence of chiral tertiary amines such as strychnine, brucine, and sparteine proceeds enantioselectively, affording appropriate amides or dipeptides in 69-85% yield. The configuration of the preferred enantiomer and enantiomeric enrichment depend on the structures of the amine and carboxylic acid. Calculated Kagan enantioselectivity parameters (s) are in the range 1.6-195. Chiral triazinylammonium chlorides formed in situ from CDMT and chiral tertiary amines are postulated as reactive intermediates involved in the process of enantioselective activation of N-protected amino acids.

A New Route toward 4-Substituted Pyrazino[2,1-b]quinazoline-3,6-dione Systems. Total Synthesis of Glyantrypine

Treatment of sodium N-(o-azidobenzoyl)aminoacylglycinates 8 with acetic anhydride afforded 1-acetyl-4-(o-azidobenzoyl)-2,5-piperazinediones 7, with complete retention of the stereochemistry. The intramolecular aza Wittig reactions of compounds 7 in the pr

Design and Synthesis of Enkephalin Analogues: Part II - Synthesis of 2, Met5>-Enkephalin Alkylamides Having Morphinomimetic Activity

Alkylamides of 2, Met5>-enkephalin have been synthesized by two different routes.The first method consists of the sequential peptidation of Phe-Met-ONBzl by 2,4,5-trichlorophenyl esters of Boc-Gly, Boc-D-Ala and Boc-Tyr to get

KINETICS OF AMINOLYSIS FOR 1-THIO-β-D-GLUCOPYRANOSYL ESTERS OF N-ACYLALANINES

The kinetics of aminolysis of 1-thio-β-D-glucopyranosyl esters of N-protected alanines (1) in dichloromethane at 26 deg C, by ethyl glycinate, under pseudo-first-order conditions follows the relationship kobsd=k2.Significant differences were obserwed in the rates of dipeptide forming aminolysis for 1-thiolesters 1a-1f, depending on N-acyl substituents and the configuration of alanine.