17684-12-7

Basic information

• Product Name: 2-methyl-3,3-diphenylacrylic acid
• Synonyms: 2-methyl-3,3-diphenylprop-2-enoic acid
• CAS NO: 17684-12-7
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.2812
• Mol File: 17684-12-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 350.3°C at 760 mmHg
• Flash Point: 252.4°C
• Density: 1.146g/cm³
• Vapor Pressure: 1.65E-05mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 2-methyl-3,3-diphenylacrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3,3-diphenylacrylic acid(17684-12-7)
• EPA Substance Registry System: 2-methyl-3,3-diphenylacrylic acid(17684-12-7)

Safety Data

• Hazardous Substances Data: 17684-12-7(Hazardous Substances Data)

Upstream product

• 119-61-9 benzophenone 
• 72959-50-3 2,6-di-tert-butyl-4-methylphenyl propionate 
• 40662-79-1 (2,6-di-t-butyl)-phenyl propanoate 
• 73198-88-6 2',6'-bis(1,1-dimethylethyl)-4'-methoxyphenyl propanoate 
• 40662-80-4 2,4,6-tri-tert-butylphenyl propionate 
• 778-66-5 1,1-diphenyl-1-propene 
• 124-38-9 carbon dioxide 
• 100-52-7 benzaldehyde 
• 13411-45-5 trimethyl(2-phenyl-1,3-dithian-2-yl)silane 
• 5908-41-8 benzoyltrimethylsilane 
• 591-50-4 iodobenzene 
• 665004-97-7 (Z)-2-methyl-3-trimethylsilyl-3-phenylpropenoic acid 
• 940964-87-4 (Z)-2-methyl-3-phenyl-3-(triethylgermyl)propenoic acid 
• 5425-44-5 2-Phenyl-[1,3]dithiane 

Downstream Products

• 13304-52-4 2-methyl-3-phenylinden-1-one 
• 5292-20-6 α-methyl-β,β-diphenylpropionic acid 

Relevant articles and documents

Practical synthesis of ynolate anions: Naphthalene-catalyzed reductive lithiation of α,α-dibromo esters

Reductive lithiation of α,α-dibromo esters using lithium naphthalenide afforded ester dianions leading to ynolate anions in good yields. Naphthalene-catalyzed reductive lithiation was also accomplished. This is a convenient, economical and practical method for the preparation of ynolate anions.

EtAlCl2/2,6-Disubstituted Pyridine-Mediated Carboxylation of Alkenes with Carbon Dioxide

α-Arylalkenes and trialkyl-substituted alkenes undergo carboxylation with CO2 in the presence of EtAlCl2 and 2,6-dibromopyridine to afford the corresponding α,β- and/or β,γ-unsaturated carboxylic acids. This reaction is suggested to proceed via the electrophilic substitution of EtAlCl2 with the aid of the base, followed by the carbonation of the resulting ate complex. This reaction can be applied to terminal dialkylalkenes by using a mixture of 2,6-di-tert-butylpyridine and 2,6-dibromopyridine.

Palladium-catalyzed fluoride-free cross-coupling of intramolecularly activated alkenylsilanes and alkenylgermanes: Synthesis of tamoxifen as a synthetic application

We have demonstrated that intramolecular hypercoordination of a carboxylic acid is a powerful activation strategy for the palladium-catalyzed cross-coupling reaction of trialkyl(vinyl)silanes and trialkyl(vinyl)germanes under fluoride-free conditions. Z-β-Trialkylsilyl- and Z-β- trialkylgermylacrylic acids, synthesized stereoselectively by olefination with ynolates, are highly stable and useful reagents for cross-coupling with a variety of aryl iodides to provide tetrasubstituted olefins possessing different carbon substituents in a stereocontrolled and diversity-oriented manner. An application to a stereoselective synthesis of (Z)-tamoxifen is also reported. Copyright