5292-20-6

Usage

Uses

Used in Pharmaceutical Industry:
2-methyl-3,3-diphenylpropanoic acid is used as an anti-inflammatory agent for its potential to reduce inflammation and alleviate pain associated with various conditions. Its anti-inflammatory properties are attributed to its ability to modulate inflammatory pathways and reduce the production of pro-inflammatory mediators.
2-methyl-3,3-diphenylpropanoic acid is also used as an analgesic agent for its potential to relieve pain by interacting with pain receptors and reducing the perception of pain signals.
Used in Neurodegenerative Disease Treatment:
In the field of neurodegenerative disease research, 2-methyl-3,3-diphenylpropanoic acid is being investigated for its potential role in treating conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Its neuroprotective properties may be attributed to its ability to modulate neuroinflammatory pathways, reduce oxidative stress, and protect neurons from degeneration.
Furthermore, 2-methyl-3,3-diphenylpropanoic acid is being explored for its potential use in drug delivery systems to enhance the bioavailability and therapeutic efficacy of other drugs targeting neurodegenerative diseases. The development of novel drug delivery systems, such as nanoparticles or liposomes, may improve the delivery of 2-methyl-3,3-diphenylpropanoic acid to the central nervous system, increasing its potential as a treatment for neurodegenerative disorders.

Upstream product

• 17684-12-7 2-methyl-3,3-diphenyl-2-propenoic acid 
• 1199-77-5 α-methylcinnamic acid 
• 71-43-2 benzene 
• 123101-42-8 tert-Butyl-3-Hydroxy-2-methyl-3,3-diphenylpropanoate 
• 114916-90-4 α-methyl-β,β-diphenyl-methyl propionate 
• 31469-22-4 1,1-bis(trimethylsilyloxy)prop-1-ene 
• 90-99-3 diphenylchloromethane 
• 7446-70-0 aluminium trichloride 
• 778-66-5 1,1-diphenyl-1-propene 
• 124-38-9 carbon dioxide 
• 5152-68-1 benzhydryl sodium 
• 535-11-5 Ethyl 2-bromopropionate 
• 119-61-9 benzophenone 
• 65127-37-9 2-methyl-3,3-diphenyl-acrylic acid ethyl ester 

Downstream Products

• 114916-90-4 α-methyl-β,β-diphenyl-methyl propionate 
• 130292-30-7 α-methyl-β,β-diphenylpropionyl chloride 
• 56406-04-3 4-Diazo-2-methyl-1,1-diphenyl-3-butanon 
• 119-61-9 benzophenone 
• 52957-74-1 2-methyl-3-phenyl-1-indanone 
• 781-33-9 2-methyl-1,1-diphenylpropene 
• 56406-06-5 1,2-dimethyl-3-phenylazulene 
• 56406-05-4 3,8a-Dihydro-2-methyl-3-phenyl-1(2H)-azulenon 
• 14275-48-0 (R)-(-)-1-methyl-2,2-diphenylcyclopropane 
• 57917-94-9 1-Methoxy-1,2-diphenyl-propan 

Relevant academic research and scientific papers

Synthesis method of succinic acid derivative or 3 -arylpropionic acid (by machine translation)

The invention discloses a synthesis method of a succinic acid derivative or 3 -arylpropionic acid, which comprises the following steps: adding a base in a drying reaction tube and CO removing CO. 2 The reaction is carried out under the irradiation of visible light, the reaction is carried out under visible light irradiation, and then separation and purification are carried out to obtain the butanedioic acid derivative or 3 -arylpropionic acid product; the base comprises sodium tert-butoxide, potassium tert-butoxide, lithium tert-butyl alcohol and 4 - potassium carbonate; and the reaction substrate comprises an acrylate compound or an aryl vinyl compound. CO can be induced by visible light. 2 The scheme provided by the invention is mild in reaction condition and wide in reaction 3 - substrate selectivity, and the reaction substrate is wide in selectivity, the raw materials are cheap and easily available, and the method has a good industrial application prospect. (by machine translation)

Lewis acid-mediated β-selective hydrocarboxylation of α,α-diaryl- and α-arylalkenes with R3SiH and CO2

α,α-Diarylalkenes are successfully hydrocarboxylated with Et3SiH and CO2 with the aid of Et3SiB(C6F5)4 or EtAlCl2/Ph3SiCl to give carboxylic acids with a carboxy group at the β-position to the aryl groups. The EtAlCl2/Ph3SiCl-mediated reaction is also applicable to various α-arylalkenes. 1H NMR analysis of a mixture of EtAlCl2, Ph3SiCl, and Et3SiH strongly suggests the formation of a μ-H complex, [Ph3Si-H-SiEt3]+ AlEtCl3-, which is an equivalent of R3Si+ ions, while Et3SiB(C6F5)4 is an ion pair with a Et3Si+ ion. Therefore, in these reaction systems, a siloxycarbonylium, R3SiOCO+, is considered to be a common electrophile, the addition of which to the substrate, followed by trapping of the resulting cationic species with Et3SiH seems to afford the desired acid after aqueous workup.

Convenient Synthetic Sequence for the Preparation of Indanones

A convenient and general methods is reported for the synthesis of indanones from aryl ketones or aldehydes.

Regioselective Lewis Acid-mediated α-sec-Alkylation of Carbonyl Compounds

Carbonyl compounds such as ketones, aldehydes, acyloins, or carboxylic esters can be alkylated at the α-position via the corresponding O-silylated forms using activated alkyl halides or acetates in the presence of Lewis acids.In the case of unsymmetricall