1086-43-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(4-methoxyphenyl)-1-indanone is utilized as a key building block in the creation of various pharmaceuticals and organic compounds. Its unique structure allows for the development of new molecules with potential therapeutic benefits.
Used in Drug Development:
In the pharmaceutical industry, 2-(4-methoxyphenyl)-1-indanone is employed as a starting material for the development of new drug candidates. Its potential biological activities, such as anti-inflammatory and anti-cancer properties, make it a promising candidate for the treatment of various diseases.
Used in Biological Research:
2-(4-methoxyphenyl)-1-indanone is also used in biological research to study its potential effects on different biological pathways and mechanisms. This research can contribute to a better understanding of the compound's therapeutic potential and guide its application in drug development.
Overall, 2-(4-methoxyphenyl)-1-indanone's diverse applications and potential therapeutic benefits have made it a valuable compound in the fields of pharmaceutical synthesis, drug development, and biological research.

Upstream product

• 100-52-7 benzaldehyde 
• 104-47-2 p-methoxybenzylnitrile 
• 637-69-4 4-Methoxystyrene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 83-33-0 inden-1-one 
• 1220094-19-8 (E)-1-formyl-2-[2-(4-methoxyphenyl)ethenyl]benzene 
• 100-44-7 benzyl chloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 5840-58-4 2-(4-methoxyphenyl)-3-phenylpropanenitrile 
• 5840-59-5 3-phenyl-2-(4-methoxyphenyl)acrylonitrile 
• 39104-22-8 3-Phenyl-2-<4-methoxy-phenyl>-propionsaeure-chlorid 
• 1769-85-3 (±)-2-(4-methoxyphenyl)-3-phenylpropanoic acid 

Downstream Products

• 107379-17-9 2-(4-Methoxyphenyl)-3-indenethiol 
• 107379-18-0 Bis<2-(4-methoxyphenyl)-3-indenyl> sulfide 
• 145962-41-0 2-(4-methoxyphenyl)indanamine 
• 145962-42-1 2-(4-methoxyphenyl)-1-indanone oxime methyl ether 
• 102345-54-0 2-<4-Methoxy-phenyl>-3-<4-(2-diaethylamino-aethoxy)-phenyl>-inden 

Relevant academic research and scientific papers

Rhodium-catalyzed intramolecular hydroacylation of 1,2-disubstituted alkenes for the synthesis of 2-substituted indanones

The intramolecular hydroacylation of 1,2-disubstituted alkenes was considered to be a challenging task due to the side reactions resulted from the lack of additional substituent at 1-position and the low activity caused by the steric hindrance of substituent at 2-position, and an asymmetric version has not been considered possible due to problems associated with the racemization of the products. We have partially solved these problems. Catalyzed by an activated diphosphine-Rh complex and reacted in a selected dihalogenated solvent, the intramolecular hydroacylation of o-(2-arylvinyl)benzaldehydes provided the corresponding 2-aryl-1-indanones in high yields, and its asymmetric variant using o-(2-alkylvinyl)benzaldehydes afforded chiral 2-alkyl-1-indanones in high yields and with moderate enantioselectivities.

Enantiodivergent Synthesis of Tertiary α-Aryl 1-Indanones: Evidence Toward Disparate Mechanisms in the Palladium-Catalyzed Decarboxylative Asymmetric Protonation

Herein, we describe a study into the scope and origin of an enantiodivergent effect in the palladium-catalyzed decarboxylative asymmetric protonation. By switching the achiral proton source, both enantiomers of a series of tertiary α-aryl-1-indanones are readily accessed from the corresponding α-aryl-β-keto allyl esters. In this example of dual stereocontrol, enantioselectivities up to 94% (S) and 92% (R) were achieved using Meldrum's acid and formic acid, respectively. In an attempt to rationalize this switch in absolute configuration an investigation of the ambiguous mechanism of the decarboxylative asymmetric protonation was conducted. A novel catalytic cycle for the reaction with formic acid is proposed and subjected to a variety of experimental studies.

AuI-catalyzed intramolecular cyclization of 2-alkenylphenyl carbonyl compounds: Exploring the oxophilic Lewis acidity of AuI species

A AuI-catalyzed intramolecular cyclization reaction of 2-alkenylphenyl carbonyl compounds to afford a variety of indene, indenol, and indanone ring systems was developed. In this process, AuI serves to activate the carbonyl group of β-keto esters, aldehydes, and ketones, preferentially exhibiting oxophilicity in the presence of C-C multiple bonds. Furthermore, β-keto esters could participate as the electrophilic partner in reactions with carbon nucleophile such as alkenes. Copyright

Inhibitors of acyl CoA:cholesterol acyltransferase

Conformational restriction of previously disclosed acyclic diphenylethyl)diphenylacetamides led to the discovery of several potent inhibitors of acyl CoA:cholesterol acyltransferase (ACAT). cis-[2-(4- Hydroxyphenyl)-1-indanyl]diphenylacetamide (4a) was the most potent ACAT inhibitor identified (IC50 = 0.04 μM in an in vitro rat hepatic microsomal ACAT assay, ED50 = 0.72 mg/kg/day in cholesterol-fed hamsters).