181289-05-4Relevant academic research and scientific papers
Synthesis of [18F]-1-(3-fluoropropyl)-4-(4-cyanohenoxymethyl)- piperidine: A potential sigma-1 receptor radioligand for PET
Collier, T. Lee,O'Brien, Joanne C.,Waterhouse, Rikki N.
, p. 785 - 794 (1996)
[18F]-1-(3-Fluoropropyl)-4-(4-cyanophenoxymethyl) piperidine has been prepared as a potential sigma-1 receptor ligand for PET. The unlabeled ligand was found to be selective in vitro for the sigma-1 receptor [Ki(σ1) = 4.3 nM] when te
Utility of azetidinium methanesulfonates for radiosynthesis of 3-[ 18F]fluoropropyl amines
Kiesewetter, Dale O.,Eckelman, William C.
, p. 953 - 969 (2007/10/03)
3-Methanesulfonyloxypropyl tertiary amines were observed to cyclize to form azetidinium methanesulfonate moieties. Heat-induced cyclization of 3-methanesulfonyloxypropyl amines was utilized for preparation of azetidinium methanesulfonates. The azetidinium methanesulfonates were found to incorporate radioactive [18F]fluoride (decay-corrected yields > 60%) efficiently, resulting in an efficient synthesis of 3-[18F] fluoropropyl tertiary amines. Copyright
