176970-12-0

Basic information

• Product Name: (S)-3-N-CBZ-AMINOPYRROLIDINE
• Synonyms: (S)-benzyl pyrrolidin-3-ylcarbamate;Carbamic acid, (3S)-3-pyrrolidinyl-, phenylmethyl ester (9CI);benzyl (S)-pyrrolidin-3-ylcarbamate;benzyl N-[(3S)-pyrrolidin-3-yl]carbamate;(S)-3-N-(Carbobenzoxy)aminopyrrolidine
• CAS NO: 176970-12-0
• Molecular Formula: C₁₂H₁₆N₂O₂
• Molecular Weight: 220.27
• Mol File: 176970-12-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 382.5 °C at 760 mmHg
• Flash Point: 185.1 °C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 4.69E-06mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: (S)-3-N-CBZ-AMINOPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-N-CBZ-AMINOPYRROLIDINE(176970-12-0)
• EPA Substance Registry System: (S)-3-N-CBZ-AMINOPYRROLIDINE(176970-12-0)

Safety Data

• Hazardous Substances Data: 176970-12-0(Hazardous Substances Data)

Usage

General Description

(S)-3-N-CBZ-aminopyrrolidine is a chemical compound that belongs to the class of amines and is commonly used in pharmaceutical research. It is also known as (S)-3-Carbobenzyloxy-aminopyrrolidine and has applications in the synthesis of various pharmaceuticals and chemicals. (S)-3-N-CBZ-AMINOPYRROLIDINE is a chiral amine, meaning it has a specific spatial arrangement of atoms, and this property makes it useful in the development of enantiomerically pure drug molecules. Its structure consists of a pyrrolidine ring with an amino group and a carbobenzyloxy (CBZ) protecting group attached to the nitrogen atom. The (S)-3-N-CBZ-aminopyrrolidine has potential uses in the development of new drugs and in the synthesis of complex organic molecules.

InChI:InChI=1/C12H16N2O2/c15-12(14-11-6-7-13-8-11)16-9-10-4-2-1-3-5-10/h1-5,11,13H,6-9H2,(H,14,15)/t11-/m0/s1

Upstream product

• 501-53-1 benzyl chloroformate 
• 176970-05-1 (S)-2-(((benzyloxy)carbonyl)amino)butane-1,4-diyl dimethanesulfonate 
• 176970-10-8 (S)-1-allyl-3-(benzyloxycarbonylamino)pyrrolidine 
• 118219-23-1 [(1S)-3-hydroxy-1-(hydroxymethyl)propyl]carbamic acid phenylmethyl ester 
• 1152-61-0 N-Cbz-L-Asp 
• 35909-93-4 dimethyl (2S)-2-[(phenylmethoxy)carbonylamino]-butane-1,4-dioate 

Downstream Products

• 247569-07-9 tert-butyl (S)-3-(((benzyloxy)carbonyl)amino)pyrrolidine-1-carboxylate 

Relevant articles and documents

Economical synthesis of tert-butyl (S)-3-aminopyrrolidine-1-carboxylate from L-aspartic acid

3-Aminopyrrolidine building block was used as the intermediate for many pharmaceutically active substances. Starting from L-aspartic acid, optically active (S)-tert-butyl-3-aminopyrrolidine-1-carboxylate was synthesized, and the reaction conditions were optimized in each step. The procedure of each step was discussed in detail and could be useful for the industrial preparation. This process was featured by readily available starting material, mild reaction conditions, easy work-up, and economy.