247569-07-9

Basic information

• Product Name: (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE
• Synonyms: (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE;(S)-tert-butyl 3-(benzyloxycarbonylamino)pyrrolidine-1-carboxylate;(S)-3-Benzyloxycarbonylamino-1-tert-butoxycarbonylpyrrolidine;tert-Butyl (3S)-3-[[(benzyloxy)carbonyl]amino]pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-[[(phenylMethoxy)carbonyl]aMino]-, 1,1-diMethylethyl ester, (3S)-
• CAS NO: 247569-07-9
• Molecular Formula: C17H24N2O4
• Molecular Weight: 320.38
• Mol File: 247569-07-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Density: 1.17
• CAS DataBase Reference: (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE(247569-07-9)
• EPA Substance Registry System: (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE(247569-07-9)

Safety Data

• Hazardous Substances Data: 247569-07-9(Hazardous Substances Data)

Usage

General Description

(S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a pyrrolidine derivative with an amino group and a BOC (tert-butoxycarbonyl) protecting group. (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE is often used as a building block in the synthesis of various pharmaceuticals and bioactive molecules. It is a valuable intermediate in the production of drugs, agrochemicals, and materials due to its versatile reactivity and functional group compatibility. Its high purity and stability make it a desirable compound for use in the development of new drugs and medical treatments. Overall, (S)-3-CBZ-AMINO-1-BOC-PYRROLIDINE is an important chemical in the field of pharmaceutical research and plays a crucial role in the production of various valuable compounds.

Upstream product

• 72925-16-7 1-boc-pyrrolidine-3-carboxylic acid 
• 100-51-6 benzyl alcohol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 176970-12-0 (S)-benzyl pyrrolidin-3-ylcarbamate 
• 501-53-1 benzyl chloroformate 
• 147081-49-0 (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester 
• 879275-77-1 (R)-benzyl pyrrolidin-3-ylcarbamate 
• 35909-93-4 dimethyl (2S)-2-[(phenylmethoxy)carbonylamino]-butane-1,4-dioate 
• 1152-61-0 N-Cbz-L-Asp 
• 118219-23-1 [(1S)-3-hydroxy-1-(hydroxymethyl)propyl]carbamic acid phenylmethyl ester 
• 849111-98-4 tert-butyl (S)-(3-benzyloxycarbonylamino-2-oxopyrrolidin-1-yl)carboxylate 
• 849111-99-5 3-benzyloxycarbonylamino-2-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 

Downstream Products

• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 887587-20-4 tert-butyl 3-(N-n-propylamino)pyrrolidine-1-carboxylate 
• 887587-15-7 3-ethylamino-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 454712-26-6 tert‐butyl 3‐(methylamino)pyrrolidine‐1‐carboxylate 
• 503067-83-2 1-(cyclopropylmethyl)-N-methylpyrrolidin-3-amine 
• 186550-13-0 3-amino-1-(t-butoxycarbonyl)pyrrolidine 

Relevant articles and documents

Pyrrolidine integrin regulator and application thereof

Disclosed are a compound as represented by formula I, and a racemate, a stereoisomer, a tautomer, an isotopic marker, a nitrogen oxide, a solvate, a polymorph, a metabolite, an ester, and a prodrug thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising same, a preparation method therefor, and the medical use thereof. The structure of formula I is as follows:

3-amino nafoxidine-containing quinazoline ketone PARP (Poly Adenosine Diphosphate Ribose Polymerase)-1/2 inhibitor as well as preparation method, medicinal composition and application thereof

The invention discloses a novel 3-amino nafoxidine-containing quinazoline-2,4(1H, 3H)-diketone PARP-1/2 (Poly Adenosine Diphosphate Ribose Polymerase) inhibitor as well as a preparation method, a medicinal composition and application thereof. Specifically, the invention relates to a 3-amino nafoxidine-containing quinazoline-2,4(1H, 3H)-diketone derivative and a medicinal salt thereof of formula (I) as shown in the specification, a preparation method thereof, a composition with one or more such compounds, preparation of the compounds, and application thereof in preparing medicines for preventing and/or treating PARP-1/2 related diseases.

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.