177035-49-3

Upstream product

• 616-30-8 3-Amino-1,2-propanediol 
• 42747-54-6 2-chloro-3,5-dinitrobenzoyl chloride 
• 2497-91-8 2-chloro-3,5-dinitrobenzoic acid 

Downstream Products

• 680199-42-2 2-(2-({[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]amino}carbonyl){2-[(methylsukfonyl)oxy]ethyl}-4,6-dinitroanilino)ethyl methanesulfonate 
• 188719-34-8 2-[Bis-(2-hydroxy-ethyl)-amino]-N-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-3,5-dinitro-benzamide 
• 188719-33-7 2-Chloro-N-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-3,5-dinitro-benzamide 
• 169527-44-0 SN 25507 

Relevant academic research and scientific papers

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

Twenty nitrogen mustard analogues derived from 5-(aziridin-l-yl)-2,4- dinitrobenzamide (CB 1954, 1) were evaluated as candidate prodrugs for gene- directed enzyme prodrug therapy (GDEPT) in Chinese hamster V79 cell lines engineered to express Escherichia

Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N- bis(2-chloroethyl)amino]-2,4-dinitrobenzamide

A series of regioisomers of the novel hypoxia-selective cytotoxin (HSC) 5- [N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (2a) have been prepared by displacement of the chloro group from methyl chlorodinitrobenzoates or the corresponding carboxamides