2497-91-8

Usage

Chemical Properties

light beige granular powder

InChI:InChI=1/C7H3ClN2O6/c8-6-4(7(11)12)1-3(9(13)14)2-5(6)10(15)16/h1-2H,(H,11,12)/p-1

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 609-99-4 3,5-dinitrosalicylic acid 
• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 118-91-2 ortho-chlorobenzoic acid 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 2213-79-8 methyl 2-chloro-3,5-dinitrobenzoate 
• 6083-67-6 2-methoxy-3,5-dinitrobenzoic acid 
• 7251-28-7 1-chloro-2,4-dinitro-6-carboethoxybenzene 
• 6083-69-8 2-Ethoxy-3,5-dinitro-benzoesaeure 
• 52040-73-0 2-phenoxy-3,5-dinitrobenzoic acid 
• 609-99-4 3,5-dinitrosalicylic acid 
• 42747-54-6 2-chloro-3,5-dinitrobenzoyl chloride 
• 609-97-2 2-amino-3,5-dinitro-benzoic acid 
• 56978-49-5 2-chloro-3,5-dinitro-benzophenone 
• 16927-43-8 2-<(4-Nitrophenyl)amino>-3,5-dinitrobenzoic acid 
• 53639-29-5 2-Dimethylamino-3,5-dinitrobenzoic acid 
• 7221-26-3 2-(phenylamino)-3,5-dinitrobenzoic acid 

Relevant academic research and scientific papers

Benzoxazinone derivatives and their use as antibacterial agents

The invention discloses benzoxazinone derivatives, a synthesis method and applications thereof. The derivatives can be used as an antibacterial agent for treating infectious diseases caused by bacteria, especially tuberculosis (TB) caused by mycobacterium. Specifically, the invention relates to compounds represented by the formula (I), pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the provided compounds; wherein the R1 to R4 are defined in the description. The invention aim to prepare novel compounds capable of inhibiting the mycobacterium activity, the compounds can be used as a potential novel drug for treating infectious diseases caused by bacteria, moreover, the compounds can be used to treat or prevent tuberculosis (TB) caused by mycobacterium, at the same time the problems related with drug resistance can be solved, and the drug metabolism property can be improved on the basis that the mycobacterium tuberculosis resistant activity is not influenced.

INHIBITORS OF STEAROYL-COA DESATURASE

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.

Anti-viral and anti-cancer agents

2-chloro-5-nitrobenzoic acid and various other chloro and nitro substitute benzoic acid derivatives are disclosed for administration in tablet or injectable solution form for the prophylaxis and therapy of neoplasm or viral infection. The active compounds have surprising efficacy in various treatment regimes and have particular application to HIV-infection and demonstrate various beneficial effects, including regression of lesions in HIV-related Kaposi's sarcoma.

Electrophilic Aromatic Substitution. Part 37. Products of Aromatic Nitrations of some Chloronitrobenzenes and Substituted Benzoic Acids in Solutions of Dinitrogen Pentaoxide and of Nitronium Salts in Nitric Acid

Yields of aromatic products of nitration in nitric acid solutions containing dinitrogen pentaoxide or nitronium salt have been determined.Evidence for the intrusion of a mechanism other than the normal nitronium ion one comes from comparison of products in the two media and from the observation of 15N NMR CIDPN effects.The additional mechanism operative with some substrates in concentrated solutions of dinitrogen pentaoxide is postulated to be one in which reversible addition of the NO3 radical is followed by combination with NO2.Dienes produced in this way can give aromatic nitroproducts by elimination of nitric acid.Nitrodecarboxylation of substituted benzoic acids occurs by a radical process.

Synthesis of Polynitrodiazophenols

The formation of diazophenols by nitration of suitably substituted anilines and rearrangement of the nitroaromatic nitramines so formed is presented.The scope of the reaction is discussed, and a mechanism for the nitramine/diazophenol rearrangement is proposed which is consistent with 15N-labeling experiments.

Reactions of Nitrophenols with Phosphorus Oxychloride in Dimethylformamide

A rapid and simple method for the replacement of hydroxyl group of nitrophenols and related compounds by chlorine using phosphorus oxychloride in dimethylformamide at ambient temperature is described.

Process for the production of nitro derivatives of aromatic compounds

Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.