177167-53-2

Basic information

• Product Name: 2,6-dichloro-4-iodobenzaldehyde
• Synonyms: 2,6-dichloro-4-iodobenzaldehyde
• CAS NO: 177167-53-2
• Molecular Weight: 300.911
• Mol File: 177167-53-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,6-dichloro-4-iodobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dichloro-4-iodobenzaldehyde(177167-53-2)
• EPA Substance Registry System: 2,6-dichloro-4-iodobenzaldehyde(177167-53-2)

Safety Data

• Hazardous Substances Data: 177167-53-2(Hazardous Substances Data)

Usage

General Description

2,6-dichloro-4-iodobenzaldehyde is a chemical compound with the molecular formula C7H3Cl2IO. It is a yellow-colored, crystalline solid that is commonly used in organic synthesis and pharmaceutical research. 2,6-dichloro-4-iodobenzaldehyde is known for its use as an intermediate in the synthesis of various organic compounds, particularly in the development of pharmaceuticals and agrochemicals. It is also used as a reagent in the preparation of diverse chemical compounds and is known for its ability to undergo various chemical reactions, including condensation, nucleophilic substitution, and oxidation reactions. Additionally, 2,6-dichloro-4-iodobenzaldehyde is classified as a hazardous substance and should be handled with caution, as it can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 3032-81-3 3,5-dichloroiodobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 177167-51-0 2,6-dichloro-4-iodobenzyl acetate 
• 177167-50-9 5-iodo-2-(bromomethyl)-1,3-dichlorobenzene 
• 177167-52-1 1,3-dichloro-5-iodo-2-methylbenzene 
• 54730-35-7 3,5-dichloro-4-methylaniline 
• 7149-69-1 1,3-dichloro-2-methyl-5-nitrobenzene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 177167-61-2 (2,6-dichloro-4-iodophenyl)methanol 

Downstream Products

• 177167-62-3 2,6-dichloro-4-<(trimethylsilyl)ethynyl>benzaldehyde 

Relevant articles and documents

Fragment-based lead discovery of a novel class of small molecule antagonists of neuropeptide B/W receptor subtype 1 (GPR7)

Here, we report the discovery of a new class of NPBWR1 antagonists identified from a fragment-based screen. Compound 1 (cAMP IC50 = 250 μM; LE = 0.29) emerged as an initial hit. Further optimization of 1 by SAR-by-catalogue and chemical modification produced 21a (cAMP IC50 = 30 nM; LE = 0.39) with a 6700-fold increase in potency from fragment 1. Somewhat surprisingly, Schild analysis of compound 21a suggested that in vitro inhibition of NPW-mediated effects on upon cAMP accumulation were saturable, and that compound 21a dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding studies. Collectively, these data are inconsistent with a classic surmountable, orthosteric mechanism of inhibition. The benzimidazole inhibitors reported herein may therefore represent a mechanistically differentiated class of compounds with which to form a better appreciation of the pharmacology and physiological roles of this central neuropeptide system.

Synthesis of regiospecifically meso-functionalized tetraarylporphyrins via arylbis(2-pyrrolyl)methanes

This paper describes the synthesis of three new porphyrins 1-3 of alternate A2B2 structure, by condensation of arylbis(2-pyrrolyl)methanes and arylaldehydes bearing suitable reactive substituents for further synthetic manipulations. This synthetic approach allows to place the reactive groups selectively on the 5,15 meso-aryls. The new porphyrins feature an ortho-nitro group in the case of 1 and a protected paraethynyl group in compounds 2 and 3. Porphyrin l, after reduction of the nitro group, is a useful intermediate for the preparation of cage or regiospecifically bis-tailed porphyrins. Compounds 2 and 3, after deprotection and Glaser-Hay coupling should give linear polymers (molecular wires) suitable for electron-transfer and light-harvesting processes.