177167-61-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(2,6-dichloro-4-iodophenyl)methanol is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs and organic compounds. Its unique chemical structure allows for the creation of a wide range of medicinal products, contributing to the development of novel treatments and therapies.
Used in Organic Chemistry:
In the field of organic chemistry, (2,6-dichloro-4-iodophenyl)methanol serves as a valuable building block for the preparation of various derivatives and functionalized molecules. Its versatility in chemical reactions enables the synthesis of a diverse array of compounds with potential applications in different industries.
Used in Antimicrobial Applications:
(2,6-dichloro-4-iodophenyl)methanol has been studied for its potential antimicrobial and antibacterial properties. It is used as an active ingredient in the development of new antimicrobial agents, which can be applied in various industries, such as healthcare, agriculture, and food preservation, to combat the growth of harmful microorganisms and improve overall safety and hygiene.
Used in Chemical Research:
As an important chemical with diverse potential applications, (2,6-dichloro-4-iodophenyl)methanol is also used in chemical research to explore new reaction pathways, develop innovative synthetic methods, and discover novel compounds with unique properties and potential uses. This research can lead to the creation of new materials, drugs, and technologies that can benefit society in various ways.

Upstream product

• 177167-51-0 2,6-dichloro-4-iodobenzyl acetate 
• 54730-35-7 3,5-dichloro-4-methylaniline 
• 3032-81-3 3,5-dichloroiodobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 177167-50-9 5-iodo-2-(bromomethyl)-1,3-dichlorobenzene 
• 177167-52-1 1,3-dichloro-5-iodo-2-methylbenzene 
• 7149-69-1 1,3-dichloro-2-methyl-5-nitrobenzene 
• 99-99-0 1-methyl-4-nitrobenzene 

Downstream Products

• 177167-62-3 2,6-dichloro-4-<(trimethylsilyl)ethynyl>benzaldehyde 
• 177167-53-2 2,6-dichloro-4-iodobenzaldehyde 

Relevant academic research and scientific papers

Fragment-based lead discovery of a novel class of small molecule antagonists of neuropeptide B/W receptor subtype 1 (GPR7)

Here, we report the discovery of a new class of NPBWR1 antagonists identified from a fragment-based screen. Compound 1 (cAMP IC50 = 250 μM; LE = 0.29) emerged as an initial hit. Further optimization of 1 by SAR-by-catalogue and chemical modification produced 21a (cAMP IC50 = 30 nM; LE = 0.39) with a 6700-fold increase in potency from fragment 1. Somewhat surprisingly, Schild analysis of compound 21a suggested that in vitro inhibition of NPW-mediated effects on upon cAMP accumulation were saturable, and that compound 21a dose-dependently increased [125I]-hNPW23 dissociation rate constants from NPBWR1 in kinetic binding studies. Collectively, these data are inconsistent with a classic surmountable, orthosteric mechanism of inhibition. The benzimidazole inhibitors reported herein may therefore represent a mechanistically differentiated class of compounds with which to form a better appreciation of the pharmacology and physiological roles of this central neuropeptide system.

SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS

The present invention relates spiro- cyclic amine derivatives of the formula (I) wherein R1; R2; R3; Q; -W-T-; R5; Z; and A have the definitions provided in the claims; or a pharmaceutically acceptable salt, a solvate or hydrate thereof or one or more N-oxides thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of diseases and conditions in which (a) SIP receptor (s) is (are) involved

Synthesis of regiospecifically meso-functionalized tetraarylporphyrins via arylbis(2-pyrrolyl)methanes

This paper describes the synthesis of three new porphyrins 1-3 of alternate A2B2 structure, by condensation of arylbis(2-pyrrolyl)methanes and arylaldehydes bearing suitable reactive substituents for further synthetic manipulations. This synthetic approach allows to place the reactive groups selectively on the 5,15 meso-aryls. The new porphyrins feature an ortho-nitro group in the case of 1 and a protected paraethynyl group in compounds 2 and 3. Porphyrin l, after reduction of the nitro group, is a useful intermediate for the preparation of cage or regiospecifically bis-tailed porphyrins. Compounds 2 and 3, after deprotection and Glaser-Hay coupling should give linear polymers (molecular wires) suitable for electron-transfer and light-harvesting processes.