177326-62-4Relevant academic research and scientific papers
Total Synthesis of Nosiheptide
Wojtas, K. Philip,Riedrich, Matthias,Lu, Jin-Yong,Winter, Philipp,Winkler, Thomas,Walter, Sophia,Arndt, Hans-Dieter
, p. 9772 - 9776 (2016)
Total synthesis of the bismacrocyclic thiopeptide antibiotic nosiheptide was achieved through the assembly of a fully functionalized linear precursor followed by consecutive macrocyclizations. Key features are a critical macrothiolactonization and a mild deprotection strategy for the 3-hydroxypyridine core. The natural product was identical to isolated authentic material in terms of spectral data and antibiotic activity.
Convenient synthesis of fragment E of antibiotic, nosiheptide
Shin, Chung-Gi,Yamada, Yasuhiro,Hayashi, Keiichiro,Yonezawa, Yasuchika,Umemura, Kazuyuki,Tanji, Tsuyoshi,Yoshimura, Juji
, p. 891 - 898 (2007/10/03)
A convenient synthesis of Fragment E, 4-hydroxymethyl-3-methylindole-2-earboxylic acid (1), from 2-methyl-3-nitrobenzyl alcohol through six steps conversion in 32 % overall yield is described.
