132351-67-8

Basic information

• Product Name: 3-(4-chlorophenyl)-4H-chroMen-4-one
• Synonyms: 3-(4-chlorophenyl)-4H-chroMen-4-one
• CAS NO: 132351-67-8
• Molecular Formula: C₁₅H₉ClO₂
• Molecular Weight: 256.68376
• Mol File: 132351-67-8.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-chlorophenyl)-4H-chroMen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-4H-chroMen-4-one(132351-67-8)
• EPA Substance Registry System: 3-(4-chlorophenyl)-4H-chroMen-4-one(132351-67-8)

Safety Data

• Hazardous Substances Data: 132351-67-8(Hazardous Substances Data)

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 122775-34-2 3-iodo-chromen-4-one 
• 52923-39-4 (E)-2'-hydroxy-4-chlorochalcone 
• 49619-82-1 3-bromo-4H-chromen-4-one 
• 17151-48-3 tributyl(4-chlorophenyl)stannane 
• 106129-86-6 1-(2-hydroxyphenyl)-3-dimethylaminoprop-2-enone 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 127820-39-7 tris(4-chlorophenyl)sulfonium trifluoromethanesulfonate 
• 1776-08-5 (E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 5575-51-9 tris(4-chlorophenyl)bismuthane 
• 13400-26-5 3-hydroxychromen-4-one 
• 491-38-3 1-benzopyran-4(4H)-one 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 142078-53-3 7a-(4-Chloro-phenyl)-1a,7a-dihydro-1,2-dioxa-cyclopropa[b]naphthalen-7-one 
• 6559-81-5 3-(4-chlorophenyl)chroman-4-one 
• 1427272-65-8 3-cyano-6-(2-hydroxylphenyl)-5-(4-chlorophenyl)pyridine-2(1H)-thione 
• 950486-83-6 C₁₇H₁₃ClN₂O 

Relevant articles and documents

Arylation of ortho-Hydroxyarylenaminones by Sulfonium Salts and Arenesulfonyl Chlorides: An Access to Isoflavones

Herein we disclose three new methods for the straightforward and efficient synthesis of 3-arylchromones following the arylation of ortho-hydroxyarylenaminones by vast diversities of bench-stable and easy-to-use sulfonium salts and arenesulfonyl chlorides.

Visible-light-mediated arylation of: Ortho -hydroxyarylenaminones: Direct access to isoflavones

In this work we highlight two new methods for the synthesis of isoflavones through consecutive domino arylation of ortho-hydroxyarylenaminones with in situ photogenerated aryl radicals. As precursors for aryl radicals we used aryl onium reagents such as diazonium and diaryliodonium salts. Notably, the photo-Meerwein arylation by aryl diazonium tetrafluoroborates demonstrated high efficiency in terms of yields and can be considered as a method of choice for the straightforward assembly of 3-aryl-substituted chromones. Ultimately, 26 compounds were prepared in good to excellent yields using the developed synthetic protocols.

Transient and Recyclable Halogenation Coupling (TRHC) for Isoflavonoid Synthesis with Site-Selective Arylation

A transient and recyclable C?H iodination has been designed for the synthesis of isoflavonoids through the domino reactions of o-hydroxyphenyl enaminones and aryl boronic acids in the presence of catalytic KI and Pd catalyst. Instead of the conventional cross-coupling strategy employing pre-halogenated substrates, this method transforms raw C?H bond by means of a transient C?H halogenation to smoothly relay the subsequent C-arylation. Consequently, such a method avoids the pre-functionalization for C?halogen bond installation as well as the generation of stoichiometric halogen-containing waste following the cross-coupled product, disclosing an intriguing new coupling protocol to forge the C?C bond in the virgin area between classical C?X (X=halogen) bond cross coupling and the C?H activation.