1776-56-3Relevant articles and documents
Single Electron Transfer-Induced Selective α-Oxygenation of Glycine Derivatives
Venugopal, Navyasree,Moser, Johannes,Vojtí?ková, Margaréta,Císa?ová, Ivana,K?nig, Burkhard,Jahn, Ullrich
supporting information, p. 405 - 412 (2021/11/03)
Modification of amino acids is an important strategy in organic and bioorganic chemistry. In contrast to common side-chain functionalization, backbone modification is much less explored. Especially glycine units seem to be attractive and versatile since a wide range of functionality can be potentially introduced. We report here oxidative modification of glycinates that are stable and enable further functionalization. Selective glycinate enolate oxidation by TEMPO or a FeCp2PF6/TEMPO reagent combination provides stable alkoxyamines in good to excellent yields. The methodology is expanded to glycine-containing dipeptides demonstrating selective oxygenation at the glycine unit. The orthogonal reactivity potential of oxygenated glycines for transformation to other amino acid derivatives is explored.
Esterification in dry media using ferric perchlorate adsorbed on silica gel
Parmar, Anupama,Kaur, Jatinder,Goyal, Rita,Kumar, Baldev,Kumar, Harish
, p. 2821 - 2826 (2007/10/03)
Adsorption of Fe(ClO4)3(H2O)6 onto chromatographic grade silica gel in the presence of alcohol ( to be used for esterification ) produces a supported reagent, Fe(ClO4)3(ROH)6/SiO2. This reagent, has been found effective for the rapid and high yield of esters, on grinding in the presence of carboxylic acids using pestle and mortar in the solid state.
