17761-74-9Relevant academic research and scientific papers
Potassium carbonate mediated unusual transformation of 2,3- dihydroquinazolinone via cascade reaction
Sharma, Moni,Mahar, Rohit,Shukla, Sanjeev K.,Kant, Ruchir,Chauhan, Prem M.S.
, p. 6171 - 6177 (2013)
An unusual potassium carbonate mediated transformation of 2,3-dihydroquinazolinone by a one-pot operation is reported under mild conditions. In addition, it is interesting to report the regioselective transformation of 3-(2-bromophenyl)-2-isopropyl-2,3-dihydroquinazolin-4(1H)-one from compound 16.
A three-component process for the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives using nanosized nickel aluminate spinel crystals as highly efficient catalysts
Safaei-Ghomi, Javad,Teymuri, Raheleh
, (2019/07/15)
NiAl2O4 spinel nanocrystals were synthesized as mesoporous catalysts and were fully characterized using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), scanning electron microscopy (SEM), and Energy-dispersive X-ray spectroscopy (EDS). These nanocrystals catalyzed the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives via a one-pot, three-component condensation reaction of aromatic aldehydes, isatoic anhydride, and ammonium acetate or primary aromatic amine under microwave irradiation. By far, the most obvious advantages of the offered process are efficiency and recyclability of the catalyst as well as a significantly shorter reaction time.
Oxone-mediated annulation of 2-aminobenzamides and 1,2-diaminobenzenes with: Sec -amines via imine- N -oxides: New syntheses of 2,3-dihydroquinazolin-4(1 H)-ones and 1 H -benzimidazoles
Sriramoju, Vinodkumar,Kurva, Srinivas,Madabhushi, Sridhar
supporting information, p. 3188 - 3191 (2018/03/06)
An efficient and mild method for the preparation of 2,3-dihydroquinazolin-4(1H)-ones and 1H-benzimidazoles by the oxone-mediated reaction of sec-amines via imine-N-oxides with 2-amino-N-substituted benzamides and 1,2-diaminobenzenes respectively in THF-wa
Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives
Xu, Wei,Zhu, Xiao-Rui,Qian, Peng-Cheng,Zhang, Xing-Guo,Deng, Chen-Liang
supporting information, p. 2851 - 2857 (2016/12/16)
We developed a copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines for the formation of quinazolinone derivatives. The strategy includes two steps (cyclization and coupling) performed in one pot. A number of substrates reacted well under standard conditions to give the corresponding quinazolinone derivatives in moderate to good yields.
Deep eutectic solvent mediated synthesis of quinazolinones and dihydroquinazolinones: Synthesis of natural products and drugs
Ghosh, Suman Kr,Nagarajan, Rajagopal
, p. 27378 - 27387 (2016/04/04)
A mild and greener protocol was developed to synthesize substituted quinazolinones and dihydroquinazolinones via deep eutectic solvent (DES) mediated cyclization with a series of aliphatic, aromatic, and heteroaromatic aldehydes in good to excellent yields. This greener strategy was further utilised to synthesize various quinazolinone natural products and drugs.
Stannous chloride in alcohol: A one-pot conversion of 2-Nitro-N- arylbenzamides to 2,3-Dihydro-1H-quinazoline-4-ones
Yoo, Choong Leol,Fettinger, James C.,Kurth, Mark J.
, p. 6941 - 6943 (2007/10/03)
A novel one-step synthesis of 2,3-dihydro-1H-quinazolin-4-ones from 2-nitrobenzamides is reported. These reactions are mediated by stannous chloride in 0.02 M methanolic or ethanolic HCl solution and proceed in good yields.
