177763-21-2Relevant academic research and scientific papers
Domino Aryne Annulation via a Nucleophilic-Ene Process
Xu, Hai,He, Jia,Shi, Jiarong,Tan, Liang,Qiu, Dachuan,Luo, Xiaohua,Li, Yang
supporting information, p. 3555 - 3559 (2018/03/21)
1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.
Pd(II)-catalyzed enantioselective intramolecular oxidative amination utilizing (+)-camphorsulfonic acid
Aebly, Andrew H.,Rainey, Trevor J.
supporting information, p. 3795 - 3799 (2017/09/15)
An enantioselective Pd(II)-catalyzed intramolecular oxidative amination reaction was developed utilizing the commercially available chiral X-type ligand (1S)-(+)-camphorsulfonic acid. The Wacker-type cyclization produced chiral indoline products with enantioselectivies up to 45% ee. Electronic structure calculations employing density functional theory support a trans-aminopalladation mechanism.
Aerobic intramolecular oxidative amination of alkenes catalyzed by NHC-coordinated palladium complexes
Rogers, Michelle M.,Wendlandt, Johanna E.,Guzei, Ilia A.,Stahl, Shannon S.
, p. 2257 - 2260 (2007/10/03)
Palladium(II) complexes bearing a single N-heterocyclic carbene ligand serve as effective catalysts for the aerobic oxidative cyclization of alkenes with pendant sulfonamides. The use of carboxylic acid cocatalysts (AcOH and PhCO2H) often leads
The reactions of N-substituted 2-(dimethylallyl)aniline compounds with phenylselanyl halides
Cooper, Matthew A.,Francis, Craig L.,Holman, Jeffrey W.,Kasum, Bruno,Taverner, Thomas,Tiekink, Edward R.T.,Ward, A. David
, p. 123 - 129 (2007/10/03)
Cyclization of the carbamate of 2-(dimethylallyl)aniline with phenylselanyl chloride (benzeneselenenyl chloride) gave a 1 : 1 mixture of a dihydroindole and a tetrahydroquinoline. With phenylselanyl bromide only the dihydroindole was obtained. Addition of
