177970-27-3

Basic information

• Product Name: 8-bromo-6-methyl-1H-3,1-benzoxazine-2,4-dione
• Synonyms: 8-bromo-6-methyl-1H-3,1-benzoxazine-2,4-dione;8-bromo-6-methylisatoic anhydride;8-broMo-6-Methyl-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione;3-Bromo-5-methylisatoic anhydride;8-Bromo-6-methyl-1H-benzo[d][1,3]oxazine-2,4-dione;2H-3,1-Benzoxazine-2,4(1H)-dione, 8-bromo-6-methyl-
• CAS NO: 177970-27-3
• Molecular Formula: C₉H₆BrNO₃
• Molecular Weight: 256
• EINECS: 1533716-785-6
• Mol File: 177970-27-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 8-bromo-6-methyl-1H-3,1-benzoxazine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromo-6-methyl-1H-3,1-benzoxazine-2,4-dione(177970-27-3)
• EPA Substance Registry System: 8-bromo-6-methyl-1H-3,1-benzoxazine-2,4-dione(177970-27-3)

Safety Data

• Hazardous Substances Data: 177970-27-3(Hazardous Substances Data)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 13091-43-5 2-amino-3-bromo-5-methylbenzoic acid 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 75-44-5 phosgene 

Relevant articles and documents

Target protein degradation inducing compound, preparation method thereof and pharmaceutical composition for preventing or treating targeted protein related diseases containing the same as an active ingredient

The present invention relates to a degraducer for inducing the decomposition of target protein, a producing method thereof, and a pharmaceutical composition for preventing or treating target protein-related diseases by containing the degraducer as an active ingredient. A novel compound represented by chemical formula 1, ULB-L-PTM, by the present invention, as a degraducer compound inducing the decomposition of target protein using cereblon E3 ubiquitin ligase, is able to significantly achieve a target protein degradation-inducing activity with an excellent binding activity of a cereblon E3 ubiquitin ligase binder thereby, being able to achieve an excellent protein degradation activity by targeting protein or polypeptide related to various diseases. The bromodomain-containing pharmaceutical composition for preventing or treating protein-related diseases or conditions contains the novel compound represented by chemical formula 1 as an active ingredient and has a useful effect of providing a health functional food composition for prevention or improvement.(AA) Example 22 (nM, 24h)COPYRIGHT KIPO 2020

A simple heterocyclic fusion reaction and its application for expeditious syntheses of rutaecarpine and its analogs

In the search for new inhibitors of cholinesterases, a simple heterocyclic fusion reaction of isatoic anhydride 8 and 3,4-dihydroisoquinoline 22 was discovered which involves a spontaneous dehydrogenation upon heating. Applying the reaction, the bioactive natural alkaloid rutaecarpine and several substituted derivatives out of tryptamines and anthranilic acids or isatoic anhydrides, respectively, can be synthesized without tedious chromatographic purification. This provides simple and fast access to larger amounts of compounds with this privileged structure in medicinal chemistry.