34916-78-4

Usage

Uses

Used in Pharmaceutical Industry:
5,6-DIMETHYL-PYRIMIDIN-4-OL is used as a key intermediate compound for the synthesis of pyrimidine derivatives, which are essential in the treatment of various medical conditions. One of its primary applications is in the preparation of pyrimidine derivatives for the treatment of α1-antitrypsin deficiency, a genetic disorder that affects the lungs and liver.
α1-antitrypsin deficiency is a condition characterized by the lack or reduced function of the α1-antitrypsin protein, which is essential for protecting the lungs from damage caused by an enzyme called neutrophil elastase. The pyrimidine derivatives synthesized using 5,6-DIMETHYL-PYRIMIDIN-4-OL have shown potential in modulating the activity of this enzyme, thereby offering a therapeutic approach to managing the symptoms and progression of the disease.

InChI:InChI=1/C6H8N2O/c1-4-5(2)7-3-8-6(4)9/h3H,1-2H3,(H,7,8,9)

Upstream product

• 28456-54-4 5,6-dimethyl-2-thiouracil 
• 1780-32-1 2,4-dichloro-5,6-dimethylpyrimidine 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 463-52-5 formamidine 
• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 71-36-3 butan-1-ol 
• 6313-33-3 formamidine hydrochloride 
• 89532-63-8 N-(3,4-dimethyl-isoxazol-5-yl)-formamide 
• 64-17-5 ethanol 

Downstream Products

• 67434-65-5 4-chloro-5,6-dimethylpyrimidine 

Relevant academic research and scientific papers

PYRIMIDINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME

The present invention provides a pyrimidine derivative represented by the formula: wherein R1p and R1q are the same or different, and each represents (1)hydrogen, (2)halogen, (3) a C1-6alkyl group which may be substituted or (4) a C1-6alkoxy group, and so on, R2 is halogen, a C1-6alkyl group, cyano group, and so on, Ar is a phenyl group which may be substituted or is a condensed hetero ring which may be substituted, which has excellent selective herbicidal activity, and a herbicide containing the derivative.

Process for preparing 4-hydroxypyrimidine

A process for preparing a 4-hydroxypyrimidine of Formula III: STR1 wherein R1 and R2 each represent a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms or an aralkyl group having 2 to 10 carbon atoms, and R4 represents hydrogen an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms, an aralkyl group having 7 to 10 carbon atoms or an aryl group having 6 to 10 carbon atoms, which comprises subjecting a 3-amino-2-unsaturated carboxylate of Formula I: STR2 wherein R1 and R2 are as defined above and R3 represents an alkyl group having 1 to 10 carbon atoms, a cycloalkyl group having 3 to 10 carbon atoms or an aralkyl group having 7 to 10 carbon atoms, and a carboxylic acid amide of Formula II: wherein R4 is as defined above, to reaction with each other in the presence of a base.