178055-99-7Relevant academic research and scientific papers
Suzuki-Miyaura coupling of aryl sulfonates with arylboronic acids using a morpholine-Pd(OAc)2 catalyst system
Abe, Taichi,Mino, Takashi,Watanabe, Kohei,Yagishita, Fumitoshi,Sakamoto, Masami
, p. 3909 - 3916 (2014/06/24)
We report a new catalyst system, a morpholine-Pd(OAc)2 complex, for Suzuki-Miyaura coupling of aryl tosylates or mesylates with arylboronic acids to give biaryl compounds. The morpholine-Pd(OAc)2 catalyst system is proposed to be a precursor of the catalytically active species in the coupling reaction. Aryl chlorides and aryl triflates can also be used in this coupling reaction. Altogether, 22 biaryl compounds were obtained using this catalyst system. We report a new catalyst system, a morpholine-Pd(OAc) 2 complex, for Suzuki-Miyaura coupling of aryl tosylates or mesylates with arylboronic acids to give biaryl compounds. The morpholine-Pd(OAc) 2 catalyst system is proposed to be a precursor of the catalytically active species in the coupling reaction. Copyright
Palladium nanoparticles supported on polyaniline nanofibers as a semi-heterogeneous catalyst in water
Gallon, Benjamin J.,Kojima, Robert W.,Kaner, Richard B.,Diaconescu, Paula L.
, p. 7251 - 7254 (2008/09/17)
(Chemical Equation Presented) A tandem catalyst for Suzuki coupling of activated or deactivated aryl chlorides and aryl boronic acids in water and for phenol synthesis from aryl chlorides in 1:1 water/dioxane was obtained by supporting palladium nanoparticles on polyaniline nanofibers (PANI; see TEM image). Thus, 2-phenylphenol was synthesized from 1,2-dichlorobenzene (see equation).
Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2′, 4′-diols as novel and potent human CHK1 inhibitors
Teng, Min,Zhu, Jinjiang,Johnson, Michael D.,Chen, Ping,Kornmann, Jill,Chen, Enhong,Blasina, Alessandra,Register, James,Anderes, Kenna,Rogers, Caroline,Deng, Yali,Ninkovic, Sacha,Grant, Stephan,Hu, Qiyue,Lundgren, Karen,Peng, Zhengwei,Kania, Robert S.
, p. 5253 - 5256 (2008/03/15)
The cocrystal structure of a library hit was used to design a novel series of CHK1 inhibitors. The new series retained the critical hydrogen-bonding groups of the resorcinol moiety for binding but lacked the phenolic anilide moiety. The newly designed com
AMINOPYRAZOLE COMPOUNDS AND USE AS CHK1 INHIBITORS
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Page/Page column 40; 59-60, (2010/02/10)
Described herein are aminopyrazole compounds of formula (I), wherein R1, R2, L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such mo
