178239-06-0

Upstream product

• 151539-25-2 (E)-3-(4-benzyloxy-3,5-dimethoxy-phenyl)prop-2-enoic acid 
• 439944-29-3 (E)-3-(4-Benzyloxy-3,5-dimethoxy-phenyl)-acrylic acid methyl ester 
• 178611-06-8 (E)-ethyl 3-(4-(benzyloxy)-3,5-dimethoxyphenyl)acrylate 
• 41628-47-1 ethyl (2E)-3-[4-hydroxy-3,5-bis(methyloxy)phenyl]-2-propenoate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 134-96-3 syringic aldehyde 
• 42041-51-0 methyl (E)-sinapate 
• 2176-18-3 4-benzyloxy-3,5-dimethoxybenzyl alcohol 
• 6527-32-8 4-(benzyloxy)-3,5-dimethoxybenzaldehyde 
• 27065-65-2 methyl 4-benzyloxy-3,5-dimethoxybenzoate 
• 530-59-6 trans-3,5-dimethoxy-4-hydroxycinnamic acid 
• 101268-11-5 4-isopropoxy-3-methoxy-trans-cinnamyl alcohol 
• 100-39-0 benzyl bromide 

Downstream Products

• 178239-12-8 (E)-3-(4-benzyloxy-3,5-dimethoxyphenyl)acrylaldehyde 
• 477770-81-3 threo-(1R,2R)-1-(4'-benzyloxy-3',5'-dimethoxyphenyl)-3-O-tosyl-1,2-glycol 
• 477770-78-8 daphneticin 
• 477770-86-8 (1S,2R)-7-hydroxy-8-[2,3-epoxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propoxy]coumarin 
• 477770-85-7 (1S,2R)-7-benzyloxy-8-[2,3-epoxy-1-(4-benzyloxy-3,5-dimethoxyphenyl)propoxy]coumarin 
• 1352451-14-9 threo-(1R,2R)-1-(4'-benzyloxy-3',5'-dimethoxyphenyl)-1-O-2''-tetrahydropyrane-2-propanol 
• 1352451-15-0 threo-(1R,2R)-1-(3',5'-dimethoxy-4'-methoxymethoxyphenyl)-1-O-2''-tetrahydropyrane-2-propanol 
• 1352451-13-8 (-)-(1R,2S)-2-(4'-allyl-2',6'-dimethoxyphenoxy)-1-(4''-hydroxy-3'',5''-dimethoxyphenyl)propan-1-ol 
• 6216-81-5 syringaresinol 

Relevant academic research and scientific papers

METHOD FOR PREPARING FUROFURAN LIGNAN COMPOUND

The present invention relates to a method for preparing a furofuran lignan compound, comprising a step of selecting and alkylating an epoxy alcohol compound and an optical isomer thereof. (+)-furofuran lignan and (?)-furofuran lignan, as well as an optical isomer thereof, can be selectively prepared by means of the method.

Synthesis of (1R,2S)-2-(4'-allyl-2',6'-dimethoxyphenoxyl)-1-(4''-hydroxy- 3'', 5''-dimethoxyphenyl)propan-1-ol

The asymmetric synthesis of the natural neolignan (1R,2S)-2-(4'-allyl-2', 6'-dimethoxyphenoxyl)-1-(4''-hydroxy-3'',5''- dimethoxyphenyl)propan-1-ol based on an asymmetric dihydroxylation as a key reaction using AD-mix-β to preparing the chiral threo-(1R,2R)-glycerol. The reaction, threo-alcohols were inverted by an SN2 reaction into erythro-(1R,2S)-isomers.

Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.

First enantioselective synthesis of daphneticin and its regioisomer

An enantioselective total synthesis of chiral daphneticin and its regioisomer is reported for the first time.

Oxazolidinedione derivatives, their production and use

2,4-Oxazolidinedione derivative represented by the formula: STR1 wherein R stands for an optionally substituted hydrocarbon residue or heterocyclic group; Y stands for a group represented by --CO--, --CH(OH)-- or --NR3 -- (wherein R3 stands for an optionally substituted alkyl group); m is 0 or 1; n is 0, 1 or 2; A stands for a C1-7 divalent aliphatic hydrocarbon group; R1 stands for hydrogen or an alkyl group; ring E stands for a benzene ring having 1 or 2 substituents; L and M respectively stand for hydrogen, or L and M may optionally be combined with each other to form a bond; with a proviso that the partial formula: STR2 does not include the formula: STR3 wherein R' stands for an alkyl group; or a salt thereof, which has excellent actions of lowering blood sugar and lipid in blood.