439944-29-3

Upstream product

• 42041-51-0 methyl (E)-sinapate 
• 100-51-6 benzyl alcohol 
• 67-56-1 methanol 
• 151539-25-2 (E)-3-(4-benzyloxy-3,5-dimethoxy-phenyl)prop-2-enoic acid 
• 6527-32-8 4-(benzyloxy)-3,5-dimethoxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 134-96-3 syringic aldehyde 
• 530-59-6 trans-3,5-dimethoxy-4-hydroxycinnamic acid 

Downstream Products

• 178239-12-8 (E)-3-(4-benzyloxy-3,5-dimethoxyphenyl)acrylaldehyde 
• 42041-51-0 methyl (E)-sinapate 
• 178239-06-0 ((E)-3-(4-benzyloxy)-3,5-dimethoxyphenyl)prop-2-en-1-ol 

Relevant academic research and scientific papers

Antioxidant and antimicrobial activity evaluation of polyhydroxycinnamic acid ester derivatives

Polyhydroxycinnamic acid esters 5a-p have been synthesized starting from the appropriately substituted benzaldehydes. The antioxidant activity of these esters has been determined by superoxide free radical scavenging activity and DPPH free radical scavenging activity. The SAR studies reveal that pyrogallol, catechol moieties are essential for good antioxidant activity and an increase in the length of alkyl chain of the ester decreases the activity. Butyl hydroxycinnamates exhibit higher antibacterial activity among the synthesized hydroxycinnamates 5a-p, but, none of these show significant antifungal activity.

Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.