178239-12-8

Upstream product

• 42041-51-0 methyl (E)-sinapate 
• 100-39-0 benzyl bromide 
• 134-96-3 syringic aldehyde 
• 178239-09-3 (E)-3-methoxy-4-(2-phenyl-4-oxazolylmethoxy)cinnamaldehyde 
• 178239-06-0 ((E)-3-(4-benzyloxy)-3,5-dimethoxyphenyl)prop-2-en-1-ol 
• 439944-29-3 (E)-3-(4-Benzyloxy-3,5-dimethoxy-phenyl)-acrylic acid methyl ester 
• 151539-25-2 (E)-3-(4-benzyloxy-3,5-dimethoxy-phenyl)prop-2-enoic acid 
• 530-59-6 trans-3,5-dimethoxy-4-hydroxycinnamic acid 
• 27065-65-2 methyl 4-benzyloxy-3,5-dimethoxybenzoate 
• 6527-32-8 4-(benzyloxy)-3,5-dimethoxybenzaldehyde 
• 2176-18-3 4-benzyloxy-3,5-dimethoxybenzyl alcohol 

Relevant academic research and scientific papers

Iron(III)/O2-Mediated Regioselective Oxidative Cleavage of 1-Arylbutadienes to Cinnamaldehydes

A simple, efficient, and environmentally benevolent regioselective oxidative cleavage of 1-arylbutadienes to cinnamaldehydes mediated by iron(III) sulfate/O2 has been developed. The reaction offered good yields and excellent regioselectivity and showed good functional group tolerance (31 examples). The method is important, as few reports with limited substrate scope are available for such excellent oxidative cleavage of conjugated dienes.

Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.

Oxazolidinedione derivatives, their production and use

2,4-Oxazolidinedione derivative represented by the formula: STR1 wherein R stands for an optionally substituted hydrocarbon residue or heterocyclic group; Y stands for a group represented by --CO--, --CH(OH)-- or --NR3 -- (wherein R3 stands for an optionally substituted alkyl group); m is 0 or 1; n is 0, 1 or 2; A stands for a C1-7 divalent aliphatic hydrocarbon group; R1 stands for hydrogen or an alkyl group; ring E stands for a benzene ring having 1 or 2 substituents; L and M respectively stand for hydrogen, or L and M may optionally be combined with each other to form a bond; with a proviso that the partial formula: STR2 does not include the formula: STR3 wherein R' stands for an alkyl group; or a salt thereof, which has excellent actions of lowering blood sugar and lipid in blood.

Thiazolidinedione derivatives, their production and use

A 2,4-thiazolidinedione derivative of the formula (I): STR1 wherein R is an optionally substituted hydrocarbon group or heterocyclic group which may be attached through a hydrocarbon chain; n is 0 or 1; X is CH or N; Y is a bivalent hydrocarbon group; Rs