17839-28-0Relevant academic research and scientific papers
Highly unusual conversion of 1-alkyl-2-(bromomethyl)aziridines into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines using methyllithium
D'Hooghe, Matthias,Kimpe, Norbert De
, p. 1275 - 1277 (2008/02/02)
1-Alkyl-2-(bromomethyl)aziridines were transformed into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines upon treatment with 2-3 equiv. of methyllithium in THF or Et2O; the peculiarity in this transformation comprises the presence of an N-ethyl
N-heterocyclic inhibitors of TNF-α expression
-
, (2008/06/13)
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
N-heterocyclic inhibitors of TNF-alpha expression
-
, (2008/06/13)
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
N- heterocyclic inhibitors of TNF-alpha expression
-
, (2008/06/13)
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
ELECTROCHEMICAL REDUCTIVE AMINATION. II. AMINATION OF ALIPHATIC ALDEHYDES WITH PRIMARY AMINES
Smirnov, Yu. D.,Pavlichenko, V. F.,Tomilov, A. P.
, p. 374 - 380 (2007/10/02)
The formation of a secondary amine by the electrolysis of an aqueous solution containing an aldehyde and a primary amine was studied.The formation of the secondary amines passes through the intermediate stage of an aldimine.The highest yield of secondary amine is attained at a molar ratio of primary amine to aldehyde of 1.2:1.As electrode material lead, cadmium, zinc, and copper may be used.As supporting electrolyte a phosphate buffer with a pH close to the pKa of the primary amine is recommended.By the method developed 32 amines with various structures were synthesized.
Stereochemistry of Aliphatic Carbocations, 12. Alkyl Shifts between Secondary Carbon Atoms
Kirmse, Wolfgang,Prolingheuer, Ernst-Christoph
, p. 104 - 128 (2007/10/02)
Several optically active, β-branched alkylamines have been synthesized from amino acids.The corresponding amines were obtained from isobutyraldehyde and 2-methylbutanal (37), respectively.The stereochemistry at the terminus of 1,2-methyl shifts has been elucidated in the nitrous acid deaminations of 4 and 21.Predominant, although incomplete inversion at the migration terminus is consistent with conformational control rather than neighboring group participation.The deamination of 31 involves a degenerate 1,2-ethyl shift and a nondegenerate 1,2-methyl shift, the reverse holds for 44.Complete inversion at the origin of the methyl migrations and the absence of subsequent retrogressive H shifts strongly support the intermediacy of methyl-bridged carbocations.Partial racemization at the origin of the ethyl migrations has been traced to proton shifts within ethyl-bridged intermediates.Rearranged open cations contribute significantly to the overall reaction if micelles are produced by self-aggregation of the alkylammonium ions.
