178603-76-4

Basic information

• Product Name: 4-FLUORONITROBENZENE
• Synonyms: 4-FLUORONITROBENZENE
• CAS NO: 178603-76-4
• Molecular Formula: C6H4FNO2
• Molecular Weight: 141.1
• EINECS: 206-502-8
• Product Categories: Fluorine series
• Mol File: 178603-76-4.mol
• Article Data: 158

Chemical Properties

• Melting Point: 21℃
• Boiling Point: 206.5°C at 760 mmHg
• Flash Point: 83.3°C
• Appearance: /
• Density: 1.337g/cm³
• Vapor Pressure: 0.34mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 4-FLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORONITROBENZENE(178603-76-4)
• EPA Substance Registry System: 4-FLUORONITROBENZENE(178603-76-4)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:
• Safety Statements: S36/37:
• Hazardous Substances Data: 178603-76-4(Hazardous Substances Data)

Usage

General Description

4-Fluoronitrobenzene is an organic chemical compound with the molecular formula C6H4FNO2. It is a pale yellow crystalline solid that is commonly used as an intermediate in the production of a variety of chemicals, including pharmaceuticals, dyes, and agrochemicals. 4-Fluoronitrobenzene is primarily used in the synthesis of other fluorinated compounds, and it is also employed as a reagent in organic reactions and as a building block in the manufacturing of specialty chemicals. 4-FLUORONITROBENZENE is considered to be hazardous to human health and the environment, and proper safety precautions should be taken when handling and storing it.

InChI:InChI=1/C6H4FNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H

Upstream product

• 462-06-6 fluorobenzene 
• 598-58-3 methyl nitrate 
• 121-73-3 3-Nitrochlorobenzene 
• 34467-53-3 p-fluoronitrobenzene anion 
• 13118-32-6 p-nitrophenyldimethylsulphonium methylsulphate 
• 29843-53-6 dimethyl(p-nitrophenyl)sulfonium perchlorate 
• 586-78-7 para-nitrophenyl bromide 
• 39055-84-0 1-chloro-4-((4-nitrophenyl)sulfonyl)benzene 
• 98-95-3 nitrobenzene 
• 7446-70-0 aluminium trichloride 
• 10544-72-6 dinitrogen tetraoxide 
• 7697-37-2 nitric acid 
• 352-34-1 4-fluoro-1-iodobenzene 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 4490-51-1 1-(4-nitrophenyl)-1H-benzo[d][1,2,3]triazole 
• 51776-70-6 2-(4-nitrophenyl)-2H-benzo[d][1,2,3]triazole 
• 103790-37-0 methyl 3-(4-nitrophenoxy)thiophene-2-carboxylate 
• 69745-31-9 2,2'-Dibutyl-4,4'-difluorazoxybenzol 
• 69745-28-4 2-(n-Butyl)-4-fluor-1-nitrosobenzol 
• 57120-34-0 p-(1-Methyl-1-cyclohexyloxy)-anilin 
• 56714-24-0 1-(p-Nitrophenoxy)-bicyclo[2.2.2]octane 
• 726-10-3 N-(4'-nitrophenyl)-2-methylaniline 
• 69745-30-8 2,2'-Dimethyl-4,4'-difluorazoxybenzol 
• 69745-27-3 4-Fluor-2-methyl-1-nitrosobenzol 
• 2109-72-0 4-tert-butoxy-1-nitrobenzene 
• 16237-47-1 1-phenylethan-1-one O-(4-nitrophenyl) oxime 
• 157911-59-6 5-[(4-nitrophenyl)amino]pyrimidine 
• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 

Relevant articles and documents

FREEZE-DRIED POTASSIUM FLUORIDE: SYNTHETIC UTILITY AS A FLUORINATING AGENT

The title reagent was found to be more effective fluorinating agent then calcine-dried potassium fluoride on a halogen-exchange fluorination.The fluorinating abilities of potassium fluoride depended strongly upon a concentration of aqueous solution to be lyophilized.

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Facile conversion of arenediazonium salts to the corresponding fluoroarenes using boron trifluoride diethyl ether complex

The conversion of various arenediazonium salts 1 to the corresponding fluoroarenes 2 has been achieved in good yields under mild conditions in boron trifluoride diethyl ether complex.

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Method for synthesizing nitro (hetero) aromatic hydrocarbon

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

The polyhedral nature of selenium-catalysed reactions: Se(iv) species instead of Se(vi) species make the difference in the on water selenium-mediated oxidation of arylamines

Selenium-catalysed oxidations are highly sought after in organic synthesis and biology. Herein, we report our studies on the on water selenium mediated oxidation of anilines. In the presence of diphenyl diselenide or benzeneseleninic acid, anilines react with hydrogen peroxide, providing direct and selective access to nitroarenes. On the other hand, the use of selenium dioxide or sodium selenite leads to azoxyarenes. Careful mechanistic analysis and 77Se NMR studies revealed that only Se(iv) species, such as benzeneperoxyseleninic acid, are the active oxidants involved in the catalytic cycle operating in water and leading to nitroarenes. While other selenium-catalysed oxidations occurring in organic solvents have been recently demonstrated to proceed through Se(vi) key intermediates, the on water oxidation of anilines to nitroarenes does not. These findings shed new light on the multifaceted nature of organoselenium-catalysed transformations and open new directions to exploit selenium-based catalysis.

Method for efficiently synthesizing fluorine-containing compound

The invention discloses a method for efficiently synthesizing a fluorine-containing compound, and relates to the field of fluorine-containing compound synthesis. The method is a method for generating a corresponding fluorine atom substituted fluorine-containing compound by reacting aromatic chloride or activated chloride serving as a raw material with potassium fluoride under the action of a novel catalyst. The method disclosed by the invention has the advantages of good product selectivity, high efficiency, mild reaction conditions, simplicity and convenience in operation, convenience in application and the like.