1788-96-1

Basic information

• Product Name: 2-methyl-3-(4-nitrophenyl)quinazolin-4(3H)-one
• Synonyms: 2-Methyl-3-(4-nitro-phenyl)-3H-quinazolin-4-one; 3-{4-nitrophenyl}-2-methyl-4(3H)-quinazolinone
• CAS NO: 1788-96-1
• Molecular Formula: C₁₅H₁₁N₃O₃
• Molecular Weight: 281.2661
• Mol File: 1788-96-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 494.2°C at 760 mmHg
• Flash Point: 252.7°C
• Density: 1.36g/cm³
• Vapor Pressure: 6.59E-10mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 2-methyl-3-(4-nitrophenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-(4-nitrophenyl)quinazolin-4(3H)-one(1788-96-1)
• EPA Substance Registry System: 2-methyl-3-(4-nitrophenyl)quinazolin-4(3H)-one(1788-96-1)

Safety Data

• Hazardous Substances Data: 1788-96-1(Hazardous Substances Data)

Upstream product

• 525-76-8 2-methyl-4-oxo-3,1-benzoxazine 
• 100-01-6 4-nitro-aniline 
• 118-92-3 anthranilic acid 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 89-52-1 o-acetylamino-benzoic acid 

Downstream Products

• 27440-42-2 3-(4-aminophenyl)-2-methyl-quinazolin-4(3H)-one 
• 133764-74-6 1-(2-Methoxy-phenyl)-3-[4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-phenyl]-thiourea 
• 133764-70-2 1-(4-Chloro-phenyl)-3-[4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-phenyl]-thiourea 

Relevant articles and documents

Synthesis, antimalarial and antibacterial activities of 3-amino acid- and aryl amine-substituted 2-methyl- 3H-quinalzolin-4-ones

A new series of 2-methyl-3H-quinazolinones substituted at the third position with amino acids (2-5) and aryl amine (6, 7) was designed, synthesized, and analyzed by infrared, NMR, and mass spectral analysis. Further, the compounds were screened for their in vivo antimalarial activity using the rodent malaria parasite Plasmodium yoelii (N-67) with the Swiss mice model. The compounds were also tested for their antibacterial activity. Birkhaueser Boston 2009.

A novel superparamagnetic powerful guanidine-functionalized γ-Fe2O3based sulfonic acid recyclable and efficient heterogeneous catalyst for microwave-assisted rapid synthesis of quinazolin-4(3H)-one derivatives in Green media

The novel organic-inorganic nanohybrid superparamagnetic (γ-Fe2O3@CPTMS-guanidine@SO3H) nanocatalyst modified with sulfonic acid represents an efficient and green catalyst for the one-pot synthesis of quinazolin-4(3H)-one derivativesviathree-component condensation reaction between anthranilic acid, acetic anhydride and different amines under microwave irradiation and solvent-free conditions (4a-q). XRD, FT-IR, FE-SEM, TGA, VSM and EDX were used to characterize this new magnetic organocatalyst. Outstanding performance, short response time (15-30 min), simple operation, easy work-up procedure, and avoidance of toxic catalysts can be regarded as its significant advantages. Moreover, it can be easily separated from the reaction solution through magnetic decantation using an external magnet, and recycled at least six times without notable reduction in its activity.

A convenient synthesis of 2-methyl-3-substituted-4(3H)-quinazolinones using bis(trichloromethyl) carbonate as condensing agent

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