17892-42-1

Basic information

• Product Name: O,O-diethylmelannein
• CAS NO: 17892-42-1
• Molecular Weight: 370.402
• Mol File: 17892-42-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O,O-diethylmelannein(CAS DataBase Reference)
• NIST Chemistry Reference: O,O-diethylmelannein(17892-42-1)
• EPA Substance Registry System: O,O-diethylmelannein(17892-42-1)

Safety Data

• Hazardous Substances Data: 17892-42-1(Hazardous Substances Data)

Upstream product

• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 82613-10-3 Ethyl m-ethoxy-p-methoxybenzoylacetate 
• 77513-51-0 ethyl 2-(3-benzyloxy-4-methoxybenzoyl) acetate 
• 82613-08-9 3-ethoxy-4-methoxybenzoyl chloride 
• 31526-71-3 3-ethoxy-4-methoxy-acetophenone 
• 2651-55-0 3-ethoxy-4-methoxybenzoic acid 
• 23428-77-5 1‐(3‐(benzyloxy)‐4‐methoxyphenyl)ethanone 
• 6100-74-9 3-hydroxy-4-methoxyacetophenone 
• 64-67-5 diethyl sulfate 
• 82613-11-4 6-Hydroxy-7-methoxy-4-(3'-ethoxy-4'-methoxyphenyl)coumarin 
• 10386-55-7 6-hydroxy-4-(3-hydroxy-4-methoxyphenyl)-7-methoxy-2H-1-benzopyran-2-one 

Downstream Products

• 2651-55-0 3-ethoxy-4-methoxybenzoic acid 
• 82613-08-9 3-ethoxy-4-methoxybenzoyl chloride 
• 17892-44-3 2-Hydroxy-3'.5-diethoxy-4.4'-dimethoxy-benzophenon 

Relevant articles and documents

An Unambiguous Synthesis of Melannein

Melannein (6-hydroxy-7-methoxy-4-(3'-hydroxy-4'-methoxyphenyl)coumarin, I) and its O,O-diethyl ether (II) have been synthesised.The steps involved in the synthesis of I and II are the respective condensation of o-methoxyhydroquinone with ethyl m-benzyloxy-p-methoxybenzoylacetate (XI) and ethyl m-ethoxy-p-methoxybenzoylacetate (III) in absolute ethyl alcohol in the presence of dry hydrogen chloride gas.The isomeric O,O-diethyl ether of melannein, viz. 6-ethoxy-7-methoxy-4(4'-ethoxy-3'-methoxyphenyl)coumarin (VI) has also been prepared by the condensation of o-methoxyhydroquinone with ethyl p-ethoxy-m-methoxybenzoylacetate (VII).The esters (III), (VII) and (XI) have been prepared by the reaction of the appropriate acetophenone derivatives with diethyl carbonate in the presence of sodium hydride.