178949-48-9Relevant academic research and scientific papers
Method and intermediates for the synthesis of korupensamines
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, (2008/06/13)
Activated isoquinolines and naphthalenes are disclosed which are useful to prepare korupensamines, michellamines and analogs thereof.
Biomimetic total synthesis of michellamines A-C
Bringmann, Gerhard,Goetz, Roland,Harmsen, Sven,Holenz, Joerg,Walter, Rainer
, p. 2045 - 2058 (2007/10/03)
The biomimetic first total synthesis of michellamines A, B, and C (1a-c), naturally occurring quateraryl alkaloids with high anti-HIV activity, is described. Key precursors are the molecular "halves" of michellamines, the antimalarial naphthylisoquinoline
Total syntheses of korupensamine C and ancistrobrevine B
Hoye, Thomas R.,Liang, Mi
, p. 3097 - 3098 (2007/10/03)
The first total syntheses of korupensamine C (3) and ancistrobrevine B (4) have been achieved. Important benzyne chemistry related to the construction of the naphthalene moiety, manipulation of methoxy groups on the tetrahydroisoquinoline unit, and hinder
The synthesis and biological activity of two analogs of the anti-HIV alkaloid michellamine B
Upender,Pollart,Liu,Hobbs,Olsen,Chao,Bowden,Crase,Thomas,Pandey,Lawson,Dawson
, p. 1371 - 1385 (2007/10/03)
Two simplified analogs of the dimeric naphthalenyltetrahydroisoquinoline alkaloid michellamine B [4',4''-didesmethoxy-2',2''-didesmethylmichellamine B and 6,8-dihydroxy-5-(1',1''-dihydroxy-2',2''-binaphthalen-4'-yl)-1R,3R-dim ethyl-1,2,3,4-tetrahydroisoqu
