178949-48-9Relevant academic research and scientific papers
Method and intermediates for the synthesis of korupensamines
-
, (2008/06/13)
Activated isoquinolines and naphthalenes are disclosed which are useful to prepare korupensamines, michellamines and analogs thereof.
The synthesis and biological activity of two analogs of the anti-HIV alkaloid michellamine B
Upender,Pollart,Liu,Hobbs,Olsen,Chao,Bowden,Crase,Thomas,Pandey,Lawson,Dawson
, p. 1371 - 1385 (2007/10/03)
Two simplified analogs of the dimeric naphthalenyltetrahydroisoquinoline alkaloid michellamine B [4',4''-didesmethoxy-2',2''-didesmethylmichellamine B and 6,8-dihydroxy-5-(1',1''-dihydroxy-2',2''-binaphthalen-4'-yl)-1R,3R-dim ethyl-1,2,3,4-tetrahydroisoqu
Biomimetic total synthesis of michellamines A-C
Bringmann, Gerhard,Goetz, Roland,Harmsen, Sven,Holenz, Joerg,Walter, Rainer
, p. 2045 - 2058 (2007/10/03)
The biomimetic first total synthesis of michellamines A, B, and C (1a-c), naturally occurring quateraryl alkaloids with high anti-HIV activity, is described. Key precursors are the molecular "halves" of michellamines, the antimalarial naphthylisoquinoline
Total syntheses of korupensamine C and ancistrobrevine B
Hoye, Thomas R.,Liang, Mi
, p. 3097 - 3098 (2007/10/03)
The first total syntheses of korupensamine C (3) and ancistrobrevine B (4) have been achieved. Important benzyne chemistry related to the construction of the naphthalene moiety, manipulation of methoxy groups on the tetrahydroisoquinoline unit, and hinder
