153379-47-6Relevant academic research and scientific papers
Design of phosphorus ligands with deep chiral pockets: Practical Synthesis of chiral β-arylamines by asymmetric hydrogenation
Liu, Guodu,Liu, Xiangqian,Cai, Zhihua,Jiao, Guangjun,Xu, Guangqing,Tang, Wenjun
, p. 4235 - 4238 (2013/05/08)
WingPhos, a C2-symmetric bisphosphorus ligand with a deep and well-defined chiral pocket was developed. It has shown high efficiency in the rhodium-catalyzed asymmetric hydrogenation of (E)-β-aryl-N-acetyl enamides, cyclic β-aryl enamides, and heterocyclic β-aryl enamides. A series of chiral β-arylisopropylamines, 2-aminotetralines, and 3-aminochromans can be synthesized with excellent ee values (nbd=3,5-norbornadiene; TON=turnover number). Copyright
Total synthesis of (ent)-korupensamine D
Hoye, Thomas R.,Chen, Minzhang
, p. 3099 - 3100 (2007/10/03)
The first total synthesis of the enantiomer of the natural product, korupensamine D (16R), is described. The key steps include a highly efficient preparation of the enantiomerically pure primary amine 4 via the ring opening of aziridine 2 with an arylcupr
The synthesis and biological activity of two analogs of the anti-HIV alkaloid michellamine B
Upender,Pollart,Liu,Hobbs,Olsen,Chao,Bowden,Crase,Thomas,Pandey,Lawson,Dawson
, p. 1371 - 1385 (2007/10/03)
Two simplified analogs of the dimeric naphthalenyltetrahydroisoquinoline alkaloid michellamine B [4',4''-didesmethoxy-2',2''-didesmethylmichellamine B and 6,8-dihydroxy-5-(1',1''-dihydroxy-2',2''-binaphthalen-4'-yl)-1R,3R-dim ethyl-1,2,3,4-tetrahydroisoqu
TOTAL SYNTHESIS OF MICHELLAMINES A-C: IMPORTANT ANTI-HIV AGENTS
Hoye, Thomas R.,Chen, Minzhang,Mi, Liang,Priest, Owen P.
, p. 8747 - 8750 (2007/10/02)
Michellamines A-C have been prepared by total synthesis in 7 and 16 linear steps from known and commercial materials, respectively.Key steps include i) palladium(0)-mediated biaryl coupling, ii) silver oxide promoted oxidative 1-naphthol coupling to an atropisomeric mixture of cross-ring quinones (indigoids), and iii) simultaneous per-debenzylation/reductive bleaching to the central 2,2'-binaphthol.
Acetogenic Isoquinoline Alkaloids, L. The Synthesis of All Possible Isomeric 6,8-Dioxygenated 1,3-Dimethyl-1,2,3,4-tetrahydroisoquinoline Methyl Ethers - Useful Chiral Building Blocks for Naphthylisoquinoline Alkaloids
Bringmann, Gerhard,Weirich, Ralf,Reuscher, Helmut,Jansen, Johannes R.,Kinzinger, Lioba,Ortmann, Thomas
, p. 877 - 888 (2007/10/02)
The practicable synthesis of all imaginable isomeric heterocyclic moieties 8-11 and ent-8-ent-11 of the naphthylisoquinoline alkaloids is described.The stereoinformation at C-3 is induced by asymmetric reductive amination, using 1-phenylethylamines of eit
