17902-22-6

Upstream product

• 1191-99-7 2,3-dihydro-2H-furan 
• 75-78-5 dimethylsilicon dichloride 
• 65-71-4 thymin 
• 1608-67-9 2-acetoxytetrahydrofuran 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 

Downstream Products

• 936095-41-9 3-(2-methoxycarbonyl-5-phenylthiophen-3-yl-methyl)-5-methyl-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione 
• 936095-23-7 3-(2-methoxycarbonylbenzyl)-5-methyl-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione 
• 936095-44-2 3-(2-carboxy-5-phenylthiophen-3-yl-methyl)-5-methyl-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione 
• 936095-47-5 3-(2-carboxy-5-phenylthiophen-3-yl-methyl)-5-methylpyrimidine-2,4-dione 
• 936095-25-9 3-(2-carboxylbenzyl)-5-methyl-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione 
• 936095-27-1 3-(2-carboxybenzyl)-5-methylpyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: Role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonis

Some N3-substituted analogues of willardiine such as 11 and 13 are selective kainate receptor antagonists. In an attempt to improve the potency and selectivity for kainate receptors, a range of analogues of 11 and 13 were synthesized with 5-sub

Synthesis of tetrahydro-2-furylated pyrimidine derivatives

The synthesis of 1-(tetrahydro-2-furyl) pyrimidine derivatives in good yields by the reaction of trimethylsilylated pyrimidine bases with 2-acetoxytetrahydrofuran using a catalytic amount of cesium chloride in acetonitrile under mild conditions is described.

FACILE SYNTHESIS OF TETRAHYDRO-2-FURYLATED PYRIMIDINES AND PURINES USING A NEW CATALYST OF CESIUM CHLORIDE

1-(Tetrahydro-2-furyl)pyrimidine and 9-(tetrahydro-2-furyl)purine derivatives were successfully synthesized in good yields by the reactions of trimethylsilylated pyrimidine and purine bases with 2-acetoxytetrahydrofuran using a new catalyst of cesium chloride in acetonitrile under mild conditions.

Method for the preparation of derivatives of uracil

A novel and very elegant method is proposed for the preparation of N1 -(2-tetrahydrofuryl)-5-substituted or -unsubstituted uracil, especially, N1 -(2-tetrahydrofuryl)-5-fluorouracil, by the reaction of the corresponding 5-substituted uracil compound with 2,3-dihydrofuran. The reaction is performed in the presence of a chlorosilane compound, e.g. dimethyldichlorosilane, and a catalytic amount of an organic amine compound and can proceed very rapidly without disadvantageous side reactions to give the objective compound with high purity in a high yield.