17975-54-1

Usage

Uses

Used in Organic Synthesis:
(4E)-3-methyl-4-[(2E)-3-phenylprop-2-en-1-ylidene]isoxazol-5(4H)-one is used as a key intermediate in organic synthesis for the development of novel compounds with potential applications in various industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (4E)-3-methyl-4-[(2E)-3-phenylprop-2-en-1-ylidene]isoxazol-5(4H)-one is utilized as a building block for the design and synthesis of new pharmaceutical agents, leveraging its unique structural features to target specific biological activities and therapeutic effects.

Upstream product

• 121-44-8 triethylamine 
• 36298-55-2 (4Z)-4-benzylidene-3-methylisoxazol-5(4H)-one 
• 141-97-9 ethyl acetoacetate 
• 104-55-2 3-phenyl-propenal 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 91-20-3 naphthalene 
• 1608-03-3 (E)-but-1-en-3-yn-1-ylbenzene 
• 935-01-3 (Z)-1-phenylbuten-3-yne 
• 275-51-4 azulene 

Relevant academic research and scientific papers

One-pot three-component synthesis of isoxazole using ZSM-5 as a heterogeneous catalyst

A mild and convenient route for the synthesis of isoxazole derivatives has been developed using ZSM-5 as a heterogeneous catalyst. The reaction was carried out under a solvent-free condition to afford the desired products in good yields. A variety of func

Green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones using ZnO@Fe3O4 core–shell nanocatalyst in water

An effective and environmentally benign methodology for the synthesis of isoxazol-5(4H)-one derivatives has been developed using a ZnO@Fe3O4 core–shell nanocatalytic system. The one-pot, multicomponent reaction of an aromatic/heteroc

Preparation and characterization of supported bimetallic gold–iron nanoparticles, and its potential for heterogeneous catalysis

Bimetallic gold–iron catalysts supported on ZrO2 and TiO2 were prepared by under potential deposition. The characterization of the catalysts was performed using an inductively coupled plasma, energy-dispersive spectroscopy, diffuse r

Facile Heterocyclic Synthesis and Antibacterial Activity of Substituted Isoxazol-5(4H)-ones

An efficient, simple, and green procedure for the synthesis of isoxazol-5(4H)-one derivatives are described here through a convenient one-pot, three-component reaction at room temperature. The title compounds are isolated in high to excellent yields and a

One-pot green synthesis of isoxazol-5(4H)-one derivatives using Dowex1-x8OH in water

4-(Arylmethylidene)-3-methylisoxazol-5(4H)-ones and 4-(arylmethylidene)-3-phenylisoxazol-5(4H)-ones were synthesized in a one-pot three-component procedure in the presence of Dowex1-x8OH as catalyst in water. The products were obtained in high yields (90-

DABCO functionalized dicationic ionic liquid (DDIL): A novel green benchmark in multicomponent synthesis of heterocyclic scaffolds under sustainable reaction conditions

A novel DABCO functionalized dicationic ionic liquid (DDIL) has been synthesized using diazabicyclo[2,2,2]octane (DABCO), 1,3-dichloro-2-propanol and NaBF4 in acetonitrile. The IL was fully characterized by IR, NMR and mass spectroscopic techniques. The presence of BF4? anion in IL was confirmed by 19F NMR and also supported by mass analysis. The TGA analysis showed that the IL is thermally stable up to 180?°C temperature. We demonstrated that the presence of the tertiary nitrogen sites and hydroxyl group in the DDIL network enhances the overall activity of DDIL. These make them compatible for base catalyzed one pot multicomponent synthesis of ortho-amino carbonitriles and 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones under grinding without solvent. In addition the activity of DDIL was also studied for synthesis of tetrahydrobenzo[b]pyrans under ultrasound irradiation in water. Furthermore the DDIL was easily recoverable and recyclable many times with modest decrease in activity.

Phthalimide-N-oxyl salts: Efficient organocatalysts for facile synthesis of (Z)-3-methyl-4-(arylmethylene)-isoxazole-5(4H)-one derivatives in water

Green and simple protocols have been developed for the synthesis of (Z)-3-methyl-4-(arylmethylene)isoxazole-5(4H)-one derivatives in the presence of tetrabutylammonium or potassium salts of phthalimide-N-oxyl, as transition metal-free catalysts, through t

An Efficient Synthesis of 4-Arylmethylidene-3-substituted-Isoxazol-5(4H)-ones in Aqueous Medium

A series of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-ones were efficiently synthesized by eco-benign, one pot uncatalyzed reaction of β-keto-ester, hydroxylamine hydrochloride, and aromatic aldehyde with electron donating substituent in water.

One-pot three-component synthesis of 3-methyl-4-arylmethylene-isoxazol- 5(4H)-ones catalyzed by sodium sulfide

3-Methyl-4-arylmethylene-isoxazol-5(4H)-ones were synthesized by the convenient three-component reaction of ethyl acetoacetate, hydroxylamine hydrochloride, and aromatic aldehydes catalyzed by sodium sulfide in the presence of ethanol at room temperature.