17987-78-9

Basic information

• Product Name: 6,8-diiodo-2-methyl-4H-3,1-benzoxazin-4-one
• Synonyms: 6,8-diiodo-2-methyl-4H-3,1-benzoxazin-4-one
• CAS NO: 17987-78-9
• Molecular Formula: C₉H₅I₂NO₂
• Molecular Weight: 412.95044
• Mol File: 17987-78-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,8-diiodo-2-methyl-4H-3,1-benzoxazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-diiodo-2-methyl-4H-3,1-benzoxazin-4-one(17987-78-9)
• EPA Substance Registry System: 6,8-diiodo-2-methyl-4H-3,1-benzoxazin-4-one(17987-78-9)

Safety Data

• Hazardous Substances Data: 17987-78-9(Hazardous Substances Data)

Upstream product

• 118-92-3 anthranilic acid 
• 108-24-7 acetic anhydride 
• 609-86-9 2-amino-3,5-diiodobenzoic acid 

Downstream Products

• 19094-52-1 2-acetylamino-3,5-diiodo-benzoic acid 

Relevant articles and documents

Design, synthesis, and biological evaluation studies of novel quinazolinone derivatives as anticonvulsant agents

In view of their expected anticonvulsant activity, some novel derivatives of 6,8-diiodo-2-methyl-3-substituted-quinazolin-4(3H)-ones (4-14) were synthesized, evaluated for their anticonvulsant activity by the maximal electroshock-induced seizure and subcutaneous pentylenetetrazole tests. The neurotoxicity was assessed using rotorod test. All the tested compounds showed considerable anticonvulsant activity in at least one of the anticonvulsant tests. Compounds 5, 6, and 8 proved to be the most potent compounds of this series with relatively low neurotoxicity and low toxicity in the median lethal dose test when compared with the reference drugs. The obtained results showed that the most potent compounds could be useful as a template for future design, optimization, and investigation to produce more active analogs.