1799-50-4

Usage

Uses

Used in Food Industry:
1,3-Pentanedione, 4,4,5,5,5-pentafluoro-1-phenylis used as a flavoring agent for its ability to impart a buttery or creamy taste to various food products. This enhances the overall flavor profile and consumer appeal of these products.
However, due to the potential health risks associated with 1,3-Pentanedione, 4,4,5,5,5-pentafluoro-1-phenyl-, there is a need for further investigation and regulation of its use in the food industry. The concerns include its classification as a respiratory irritant and a potential hazard for respiratory sensitization, as well as the suggested link to the development of bronchiolitis obliterans, a serious lung disease. As a result, it is crucial to evaluate the safety and potential alternatives to ensure the well-being of consumers.

Upstream product

• 378-75-6 perfluoropropionic acid methyl ester 
• 98-86-2 acetophenone 
• 428-59-1 Hexafluoropropene oxide 
• 7196-01-2 4-(1-phenylvinyl)morpholine 
• 426-65-3 ethyl Pentafluoropropionate 

Downstream Products

• 77063-22-0 1,1,1,2,2-pentafluoro-4-phenyl-4-pentyn-2-one 
• 255819-19-3 Rh(C₁₁H₆O₂F₅)3 
• 92462-14-1 Benzoic acid N'-[(Z)-4,4,5,5,5-pentafluoro-3-hydroxy-1-phenyl-pent-2-en-(Z)-ylidene]-N-phenyl-hydrazide 

Relevant academic research and scientific papers

α-Pentafluoropropionylation of Ketones and Aldehydes Using Hexafluoropropene Oxide. A Facile Synthesis of Fluorinated 1,3-Diketones

Hexafluoropropene oxide reacts smoothly with morpholine enamines from ketones and aldehydes at 0 deg C to room temperature in anhydrous THF to give pentafluorinated 1,3-diketones in good yields.The keto-enol equilibrium in the products is generally in favor of their enol form.

Regioselective synthesis of 4-alkyl- and 4-aryl-6-(perfluoroalkyl)salicylic acid derivatives by formal [3+3] cyclocondensation of 1,3-bis(silyloxy)-1,3-butadienes with 3-silyloxy-1-(perfluoroalkyl)prop-2-en-1-ones

4-Alkyl- and 4-aryl-6-(perfluoroalkyl)salicylic acid derivatives were regioselectively prepared by [3+3] cyclization of 1,3-bis(silyl enol ethers) with 3-silyloxy-1-(perfluoroalkyl)prop-2-en-1-ones.

Modulators of LXR

Compounds, compositions and methods for modulating the activity of nuclear receptors are provided. In particular, heterocyclic compounds are provided for modulating the activity of nuclear receptors, including liver X receptor (LXR) and orphan nuclear receptors. In certain embodiments, the compounds are N-substituted pyridones.