179983-39-2

Basic information

• Product Name: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid
• Synonyms: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid
• CAS NO: 179983-39-2
• Molecular Weight: 385.25
• Mol File: 179983-39-2.mol

Chemical Properties

• CAS DataBase Reference: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid(179983-39-2)
• EPA Substance Registry System: 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid(179983-39-2)

Safety Data

• Hazardous Substances Data: 179983-39-2(Hazardous Substances Data)

Upstream product

• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 
• 128293-62-9 ethyl 4-amino-1-methylimidazole-2-carboxylate 
• 288625-59-2 ethyl 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylate 
• 89088-57-3 ethyl 3-amino-1-methyl-1H-pyrazole-5-carboxylate 
• 15944-88-4 4-[N,N-bis(2-chloroethyl)amino]benzoyl chloride 

Relevant articles and documents

DNA sequence-recognizing properties of minor groove alkylating agents / Effects of the replacement of N-methylpyrrole by an N-methylimidazole on tallimustine and its own homologue

The linkage of an heterocycle, like N-methylimidazole, to minor DNA groove binders containing two or three pyrroles lead to a new class of oligopeptides with reduced antitumor activity both in vitro and in vivo if compared to tallimustine (CAS 115308-98-0) and its tetrapyrrole homologue 9. In the present paper is reported the correlation between the cytoxicity of tallimustine and its derivatives 9-11 with their ability to inhibit polymerase chain reaction (PCR) amplification of oestrogen receptor and Ha- ras gene sequences, containing A+T rich and G+C rich regions, respectively. Tallimustine and its tetrapyrrole homologue 9 were found to have higher sequence selectivity for the human oestrogen receptor (ER) gene with respect to the relative imidazole-containing analogues.

Synthesis and antitumor activity of novel distamycin derivatives

Several distamycin derivatives were synthesized from deformyl distamycin by coupling with different azole carboxylic acids bearing an alkylating moiety. Some of them showed good activities in vitro and in vivo against L 1210 murine leukemia.