288625-59-2

Upstream product

• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 
• 128293-62-9 ethyl 4-amino-1-methylimidazole-2-carboxylate 
• 15944-88-4 4-[N,N-bis(2-chloroethyl)amino]benzoyl chloride 

Downstream Products

• 179983-39-2 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid 

Relevant academic research and scientific papers

DNA sequence-recognizing properties of minor groove alkylating agents / Effects of the replacement of N-methylpyrrole by an N-methylimidazole on tallimustine and its own homologue

The linkage of an heterocycle, like N-methylimidazole, to minor DNA groove binders containing two or three pyrroles lead to a new class of oligopeptides with reduced antitumor activity both in vitro and in vivo if compared to tallimustine (CAS 115308-98-0) and its tetrapyrrole homologue 9. In the present paper is reported the correlation between the cytoxicity of tallimustine and its derivatives 9-11 with their ability to inhibit polymerase chain reaction (PCR) amplification of oestrogen receptor and Ha- ras gene sequences, containing A+T rich and G+C rich regions, respectively. Tallimustine and its tetrapyrrole homologue 9 were found to have higher sequence selectivity for the human oestrogen receptor (ER) gene with respect to the relative imidazole-containing analogues.