1800340-40-2Relevant academic research and scientific papers
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design
Ahuja, Vijay,Delucca, George,Dodd, Dharmpal,Everlof, Gerry,Gavai, Ashvinikumar V.,Gill, Patrice,Han, Wen-Ching,Harikrishnan, Lalgudi,Huang, Christine,Hunt, John T.,Huynh, Tram,Kamau, Muthoni,Lee, Francis Y.,Li, Jianqing,Li, Peng,Marsilio, Frank,Mathur, Arvind,Menard, Krista,Mussari, Christopher,Norris, Derek,O'Malley, Daniel,Poss, Michael,Quesnelle, Claude,Raghavan, Nirmala,Rampulla, Richard,Ranasinghe, Asoka,Sheriff, Steven,Sun, Dawn,Tokarski, John S.,Tortolani, David,Traeger, Sarah C.,Tye, Ching Kim,Vaccaro, Wayne,Vite, Gregory,Wee, Susan,Wen, Mei-Li,Westhouse, Richard,Wu, Dauh-Rurng,Yan, Chunhong,Yang, Zheng,Yip, Henry,Zhang, Haiying,Zhang, Huiping,Zhang, Yingru,Zhao, Yufen
, p. 14247 - 14265 (2021/10/12)
Inhibition of the bromodomain and extra-terminal (BET) family of adaptor proteins is an attractive strategy for targeting transcriptional regulation of key oncogenes, such as c-MYC. Starting with the screening hit 1, a combination of structure-activity re
NOVEL TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
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Paragraph 0347; 0348; 0435, (2016/07/27)
The present invention is directed to tricyclic compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS
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Page/Page column 68; 69; 103; 104, (2015/07/15)
The present invention is directed to tricyclic compounds (I), pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
