180194-80-3

Upstream product

• 2402-97-3 3-bromopyridine N-oxide 
• 626-55-1 3-Bromopyridine 
• 180194-75-6 4-nitro-3-(4-chlorophenoxy)pyridine N-oxide 
• 106-48-9 4-chloro-phenol 
• 1678-49-5 3-Bromo-4-nitropyridine N-oxide 
• 124-63-0 methanesulfonyl chloride 
• 180194-77-8 4-amino-3-(4-chlorophenoxy)pyridine 

Relevant academic research and scientific papers

Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors

In this study, we report the synthesis and pharmacological evaluation of original pyridinic sulfonamides related to nimesulide, a cyclooxygenase-2 (COX-2) preferential inhibitor widely used as an anti-inflammatory agent. These original pyridinic derivativ

Synthesis and pharmacological evaluation of derivatives structuraily related to nimesulide

The present work reports the synthesis of a series of compounds structurally related to the antiinflammatory and antihistaminic agent nimesulide (I), in which the p-nitrophenyl moiety has been replaced by pyridine (1a-c) and pyridine N-oxide (2a-c). In addition, two compounds (3a, 4a) have been synthesized in which the p-nitro group of I was substituted by a cyano and a 1H-tetrazol-5-yl group, respectively. Representative 1a and 2a were also modified by replacing the methanesulfonamido group with an acetamido group (5a, 6a). The pharmacological evaluation of compounds 1-6 in comparison to I, indicates that such modifications are detrimental to the activity. Moreover 3a and 4a caused bronchoconstriction and hypotension, thus behaving as histaminic-like rather then antihistaminic agents.