1802-34-2

Usage

Uses

Used in Pharmaceutical Research:
3-(3-phenylpropyl)pyridine is utilized as a potential drug candidate for its ability to engage with multiple biological targets. It is recognized for its potential anti-inflammatory, anti-cancer, and anti-depressant properties, which make it a promising molecule for the development of new therapeutic agents.
Used in Neurological Disorder Treatments:
In the field of neurology, 3-(3-phenylpropyl)pyridine is studied for its capacity to modulate certain neurotransmitter systems in the brain. This characteristic positions it as a potential target for the treatment of various neurological disorders, offering new avenues for therapeutic intervention.

InChI:InChI=1/C14H15N/c1-2-6-13(7-3-1)8-4-9-14-10-5-11-15-12-14/h1-3,5-7,10-12H,4,8-9H2

Upstream product

• 100-42-5 styrene 
• 108-99-6 3-Methylpyridine 
• 1802-36-4 3-phenyl-1-(3-pyridinyl)-1-propanone 
• 100-54-9 pyridine-3-carbonitrile 
• 103-63-9 1-phenyl-2-bromoethane 
• 1120-90-7 3-iodopyridine 
• 300-57-2 allylbenzene 
• 626-55-1 3-Bromopyridine 
• 637-59-2 1-Bromo-3-phenylpropane 
• 104-52-9 phenylpropyl chloride 
• 3468-53-9 phenyl nicotinate 
• 180286-97-9 9-(3-phenylpropyl)-9-borabicyclo[3.3.1]nonane 
• 626-60-8 3-Chloropyridine 
• 1121-55-7 3-vinylpyridine 

Downstream Products

• 34122-28-6 4-(3-phenylpropyl)pyridine N-oxide 

Relevant academic research and scientific papers

Ruthenium catalyzed β-selective alkylation of vinylpyridines with aldehydes/ketonesviaN2H4mediated deoxygenative couplings

Umpolung (polarity reversal) tactics of aldehydes/ketones have greatly broadened carbonyl chemistry by enabling transformations with electrophilic reagents and deoxygenative functionalizations. Herein, we report the first ruthenium-catalyzed β-selective alkylation of vinylpyridines with both naturally abundant aromatic and aliphatic aldehyde/ketonesviaN2H4mediated deoxygenative couplings. Compared with one-electron umpolung of carbonyls to alcohols, this two-electron umpolung strategy realized reductive deoxygenation targets, which were not only applicable to the regioselective alkylation of a broad range of 2/4-alkene substituted pyridines, but also amenable to challenging 3-vinyl and steric-embedded internal pyridines as well as their analogous heterocyclic structures.

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross-electrophile coupling of aryl chlorides with alkyl chlorides has remained a chall

Switchable Selectivity in the Pd-Catalyzed Alkylative Cross-Coupling of Esters

The Pd-catalyzed cross-coupling of phenyl esters and alkyl boranes is disclosed. Two reaction modes are rendered accessible in a selective fashion by interchange of the catalyst. With a Pd-NHC system, alkyl ketones can be prepared in good yields via a Suzuki-Miyaura reaction proceeding by activation of the C(acyl)-O bond. Use of a Pd-dcype catalyst enables alkylated arenes to be synthesized by a modified pathway with extrusion of CO. Applications of this divergent coupling strategy and the origin of the switchable selectivity are discussed.

Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides

An efficient method for the preparation of alkyl indium reagents by using unactivated and cheap alkyl chlorides as substrates in the presence of indium and LiI was developed. The thus-formed alkyl indium species effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.

Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling

Despite their importance, the synthesis of alkylated heterocycles from the cross-coupling of Lewis basic nitrogen heteroaryl halides with alkyl halides remains a challenge. We report here a general solution to this challenge enabled by a new collection of ligands based around 2-pyridyl-N-cyanocarboxamidine and 2-pyridylcarboxamidine cores. Both primary and secondary alkyl halides can be coupled with 2-, 3-, and 4-pyridyl halides as well as other more complex heterocycles in generally good yields (41 examples, 69% ave yield).

Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates

The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive anti-Markovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

Bis-benzo or benzopyrido cyclohepta piperidene, piperidylidene and piperazine compounds, compositions and methods of use

Bis-benzo or benzopyrido piperidene, piperidylidene and piperazine compounds of the formula: STR1 and pharmaceutically acceptable salts thereof are disclosed, wherein Z represents --(C(Ra)2)m --Y--(C(Ra)2)n -- or STR2 The compounds of Formula I possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.

HOMOLYTIC ADDITION OF ALKYLPYRIDINES TO PHENYLACETYLENE

The homolytic addition of 2-, 3-, and 4-methylpyridines and 2-methyl-5-ethylpyridine to phenylacetylene was studied under the conditions of peroxide initiation.The important role of polar factors in the reagents, affecting both the yields of 1-phenyl-3-pyridyl-1-alkenes and the ratio of cis and trans isomers, was demonstrated.

Benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use

Novel benzopyrido piperidiene, piperidylidene and piperazine compounds of the generalized formula STR1 are disclosed as useful for the treatment of asthma, allergy and inflammation. Novel pharmaceutical compositions containing such compounds and processes for producing the compounds are also disclosed.