18022-66-7

Basic information

• Product Name: 3,4-DIMETHYL-3-CYCLOHEXENYLMETHANAL
• Synonyms: 3,4-DIMETHYL-3-CYCLOHEXENYLMETHANAL;3,4-Dimethyl-3-cyclohexene-1-carboxaldehyde;3,4-Dimethyl-3-cyclohexenecarbaldehyde;3,4-Dimethylcyclohex-3-enecarbaldehyde;4-Formyl-1,2-dimethyl-1-cyclohexene;3,4-Dimethyl-3-cyclohexenecarboxaldehyde
• CAS NO: 18022-66-7
• Molecular Formula: C₉H₁₄O
• Molecular Weight: 138.20686
• Mol File: 18022-66-7.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 79°C/10mmHg(lit.)
• Appearance: /
• Density: 0.971±0.06 g/cm3(Predicted)
• Refractive Index: n20/D1.477-1.481
• Storage Temp.: 2-8°C
• BRN: 2040252
• CAS DataBase Reference: 3,4-DIMETHYL-3-CYCLOHEXENYLMETHANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHYL-3-CYCLOHEXENYLMETHANAL(18022-66-7)
• EPA Substance Registry System: 3,4-DIMETHYL-3-CYCLOHEXENYLMETHANAL(18022-66-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 18022-66-7(Hazardous Substances Data)

Usage

Uses

3,4-Dimethyl-3-cyclohexenecarboxaldehyde is used in preparation of secondary Amine compounds as tRNA synthetase inhibitors useful in killing Gram-negative bacteria.

Upstream product

• 513-81-5 2,3-dimethyl-buta-1,3-diene 
• 107-02-8 acrolein 
• 76-09-5 2,3-dimethyl-2,3-butane diol 

Downstream Products

• 39155-41-4 (3,4-dimethylcyclohex-3-en-1-yl)methanol 
• 95-47-6 o-xylene 
• 95-63-6 1,2,4-Trimethylbenzene 
• 1674-10-8 1,2-dimethylcyclohexene 
• 74454-23-2 1-(3,4-dimethyl-cyclohex-3-enyl)-propan-1-ol 
• 90769-69-0 1,2,4-trimethylcyclohex-1-ene 
• 119336-62-8 (4R,6R)-2-((R)-3,4-Dimethyl-cyclohex-3-enyl)-4,6-dimethyl-[1,3]dioxane 
• 119336-62-8 (4R,6R)-2-((S)-3,4-Dimethyl-cyclohex-3-enyl)-4,6-dimethyl-[1,3]dioxane 
• 2952-87-6 1-(3,4-Dimethyl-cyclohex-3-enyl)-but-3-en-1-ol 
• 74454-12-9 4-(1-acetoxy-propyl)-1,2-dimethyl-cyclohexene 
• 74454-07-2 4-(1-acetoxy-ethyl)-1,2-dimethyl-cyclohexene 
• 74235-35-1 3.4-Dimethyl-3-cyclohexen-1.1-dimethanol 

Relevant articles and documents

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Poly(ethylene glycol)-Supported Chiral Imidazolidin-4-one: An Efficient Organic Catalyst for the Enantioselective Diels-Alder Cycloaddition

A tyrosine-derived imidazolidin-4-one was immobilized on a modified poly(ethylene glycol) and converted in situ into a soluble polymer-supported catalyst for the enantioselective Diels-Alder cycloaddition of acrolein to 1,3-cyclohexadiene (up to 92% ee) a

Polyesters Containing Chiral Imidazolidinone Salts in Polymer Main Chain: Heterogeneous Organocatalysts for the Asymmetric Diels–Alder Reaction

Novel main-chain polyesters functionalized with chiral imidazolidinone salts were successfully synthesized. Polycondensation of a chiral imidazolidinone dimer bearing two hydroxyphenyl groups with selected achiral dicarboxylic acid chlorides followed by t

Selective production of bio-based: Para -xylene over an FeOx -modified Pd/Al2O3catalyst

para-Xylene (PX) is a basic building block of polyethylene terephthalate, which is currently produced from petroleum resources. Developing a renewable route to PX is highly desirable to address both economic and environmental concerns. Several attempts used noble metal catalysts, e.g. Pd/Al2O3, to synthesize PX from biomass-derived 4-methyl-3-cyclohexene-1-carboxaldehyde (4-MCHCA), but suffered from a severe decarbonylation reaction, resulting in toluene as the main product. In this paper, we report an FeOx modification strategy to suppress the decarbonylation reaction on a Pd/Al2O3 catalyst, leading to a drastic shift in selectivity towards PX with a yield up to 81percent via a cascade dehydroaromatization-hydrodeoxygenation (DHA-HDO) pathway. Characterization and control experiments revealed that the electron density of Pd sites decreased in an FeOx-modified Pd/Al2O3 catalyst compared to Pd/Al2O3, thus tuning the preferential adsorption mode of the substrate from η2-(C,O), the key transition state of the decarbonylation reaction, to the η1-(O) mode that favors the hydrodeoxygenation process. Notably, this designed catalyst is highly stable and is readily applicable in the selective synthesis of a broad range of desired aromatic chemicals via the same DHA-HDO pathway from cyclohex-3-enecarbaldehyde derivatives. Overall, this work develops a controllable catalyst modification strategy that tailors an efficient catalyst for petroleum-independent bio-PX synthesis.

Synthesis of Main-Chain Ionic Polymers of Chiral Imidazolidinone Organocatalysts and Their Application to Asymmetric Diels–Alder Reactions

Main-chain ionic polymers incorporating chiral imidazolidinone moieties in the polymer main chain were successfully synthesized by the polyaddition reaction of a chiral imidazolidinone dimer with a disulfonic acid. The organocatalytic activities of these polymers were investigated in the asymmetric Diels–Alder reaction between trans-cinnamaldehyde and 1,3-cyclopentadiene. The catalytic performance of the polymers was found to be sensitive to the chemical structure of the disulfonate units and the imidazolidinone dimer. With the use of these heterogeneous polymeric chiral organocatalysts, enantioselectivities of up to 99% for the endo isomer were obtained. This result was higher than those obtained with corresponding monomeric and dimeric counterparts in a homogeneous solution. The polymeric chiral organocatalyst was recovered and reused several times, maintaining its high enantioselectivity. (Figure presented.).