765895-95-2

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 97513-47-8 2-(4-bromophenyl)-4-chloro-6-methylpyrimidine 
• 180606-52-4 2-(4-bromophenyl)-6-methylpyrimidin-4-one 
• 623-00-7 4-bromobenzenecarbonitrile 
• 55368-42-8 4-bromobenzamidine hydrochloride 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists

Through preparation and examination of a series of novel 4-amino-2-phenylpyrimidine derivatives as agonists for GPR119, we identified 2-(4-bromophenyl)-6-methyl-N-[2-(1-oxidopyridin-3-yl)ethyl]pyrimidin-4-amine (9t). Compound 9t improved glucose tolerance in mice following oral administration and showed good pharmacokinetic profiles in rats.